The connexin family of channel-forming proteins is present in every tissue type in the human
anatomy. Connexins are best known for forming clustered intercellular channels, structurally …

Evaluation of the human genome suggests that all members of the connexin family of gap-
junction proteins have now been successfully identified. This large and diverse family of …

Vertebrate gap junctions, composed of proteins from the connexin gene family, play critical
roles in embryonic development, co-ordinated contraction of excitable cells, tissue …

Gap junctions allow the exchange of ions, second messengers, and small metabolites
between adjacent cells and are formed by two unrelated protein families, the pannexins and …

Gap junctions, composed of proteins from the connexin gene family, are highly dynamic
structures that are regulated by kinase-mediated signaling pathways and interactions with …

ATP has been shown to be a taste bud afferent transmitter, but the cells responsible for, and
the mechanism of, its release have not been identified. Using CHO cells expressing high …

Gap junctions and hemichannels comprised of connexins impact many cellular processes.
Significant advances in our understanding of the functional role of these channels have …

Injury to the skin initiates a cascade of events including inflammation, new tissue formation,
and tissue remodeling, that finally lead to at least partial reconstruction of the original tissue …

OBJECTIVE—Dynamically regulated expression of the gap junction protein connexin (Cx)
43 plays pivotal roles in wound healing. Cx43 is normally downregulated and Cx26 …

Selective vulnerability is an enigmatic feature of neurodegenerative diseases (NDs),
whereby a widely expressed protein causes lesions in specific cell types and brain regions …