Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease or Charcot
disease, is a fatal neurodegenerative disease that affects motor neurons (MNs) and leads to …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by
the loss of motor neurons in the brain and spinal cord. While the exact causes of ALS are still …

Abstract p38 mitogen-activated protein kinases (P38α and β) and c-Jun N-terminal kinases
(JNK1, 2, and 3) are key mediators of the cellular stress response. However, prolonged P38 …

This work was designed to clarify the absolute abundances of transporters and receptors at
different cerebral regions of the blood–brain barriers (BBB) and blood–spinal cord barrier …

Amyotrophic lateral sclerosis (ALS) is manifested as skeletal muscle denervation, loss of
motor neurons and finally severe respiratory failure. Mutations of RNA-binding protein FUS …

Numerous potential amyotrophic lateral sclerosis (ALS)‐relevant pathways have been
hypothesized and studied preclinically, with subsequent translation to clinical trial. However …

Amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease, involves the rapid
deterioration of motor neurons resulting in severe muscle atrophy and respiratory …

Intranasal administration is a promising route for direct drug delivery to the brain; its
combination with nanocarriers enhances delivery. We have previously shown that intranasal …

Following the discovery of the involvement of the ribonucleoprotein TDP‐43 in amyotrophic
lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), a major research …

Mitochondrial dysfunction can arise from genetic defects or environmental exposures and
impact a wide range of biological processes. Among these are metabolic pathways involved …