Recent advances in machine learning and experimental biology have offered breakthrough
solutions to problems such as protein structure prediction that were long thought to be …

T cells are essential immune cells responsible for identifying and eliminating pathogens.
Through interactions between their T-cell antigen receptors (TCRs) and antigens presented …

Studies have demonstrated that at least 20% of individuals infected with SARS-CoV-2
remain asymptomatic,,–. Although most global efforts have focused on severe illness in …

Neoepitopes arising from amino acid substitutions due to single nucleotide polymorphisms
are targets of T cell immune responses to cancer and are of significant interest in the …

Antigen immunogenicity and the specificity of binding of T-cell receptors to antigens are key
properties underlying effective immune responses. Here we propose diffRBM, an approach …

Human leukocyte antigen (HLA) molecules present small peptide antigens to T cells,
thereby allowing them to recognize pathogen-infected and cancer cells. A central dogma …

HLA-A* 11: 01 is one of the most prevalent human leukocyte antigens (HLAs), especially in
East Asian and Oceanian populations. It is also highly expressed in Indigenous people who …

The class I proteins of the major histocompatibility complex (MHC-I) display epitopic
peptides derived from endogenous proteins on the cell surface for immune surveillance …

Introduction Neoantigen-based immunotherapy has emerged as a promising strategy for
improving the life expectancy of cancer patients. This therapeutic approach heavily relies on …

Motivation Computationally predicting major histocompatibility complex class I (MHC-I)
peptide binding affinity is an important problem in immunological bioinformatics, which is …