A Bird's-Eye View of the Pathophysiologic Role of the Human Urobiota in Health and Disease: Can We Modulate It?

E Jirillo, R Palmirotta, M Colella, L Santacroce - Pathophysiology, 2024 - mdpi.com
For a long time, urine has been considered sterile in physiological conditions, thanks to the
particular structure of the urinary tract and the production of uromodulin or Tamm–Horsfall …

Plant-derived SAC domain of PAR-4 (Prostate Apoptosis Response 4) exhibits growth inhibitory effects in prostate cancer cells

S Sarkar, S Jain, V Rai, DK Sahoo, S Raha… - Frontiers in plant …, 2015 - frontiersin.org
The gene Par-4 (Prostate Apoptosis Response 4) was originally identified in prostate cancer
cells undergoing apoptosis and its product Par-4 showed cancer specific pro-apoptotic …

Evaluation of G2013 (α‐L‐guluronic acid) efficacy on PC‐3 cells through inhibiting the expression of inflammatory factors

Z Bagherian, A Mirshafiey… - Clinical and …, 2022 - Wiley Online Library
Given multiple treatment strategies for prostate cancer, its mortality rate is still high;
therefore, novel treatment strategies seem necessary. G2013 or α‐L‐guluronic acid is a new …

[HTML][HTML] Микробиота желудочно-кишечного тракта и канцерогенез в различных органах человека

РК Костин, ДА Малюгин, ЛГ Соленова… - Журнал …, 2023 - cyberleninka.ru
Научные исследования последних лет выявили существенную роль микробиома
человека в канцерогенезе, что послужило обоснованием включения полиморфных …

mTOR inhibitors for treatment of low-risk prostate cancer

MA Liss, L Rickborn, J DiGiovanni, D Bacich… - Medical hypotheses, 2018 - Elsevier
Prostate cancer incidence increases with age; along with many other cancers, it could be
considered a disease of aging. Prostate cancer screening has led to a significant proportion …

[引用][C] 内毒素介导的炎症反应机制和多酚类化合物抗炎治疗的研究进展

邢静, 李玉玲, 张彧, 代旭亮, 李锐, 高冬娜, 杨娑娑… - 中华危重症医学杂志: 电子版, 2016

Gut microbiota and carcinogenesis in various human organs

RK Kostin, DA Malyugin, LG Solenova… - Journal of …, 2023 - microbiol.crie.ru
Scientific research in recent years has revealed a significant role of the human microbiome
in carcinogenesis. These data served as a rationale for the inclusion of polymorphic …

Association between the anticancer efficacy of cabazitaxel and toll-like receptor 4 mediating signaling pathways in metastatic castration-resistant prostate cancer cells

G Guney Eskiler, AD Ozkan… - Human & …, 2021 - journals.sagepub.com
Background: We evaluated the effect of cabazitaxel (CAB) as a third-line taxane on Toll-like
receptor 4 (TLR4)-mediated signaling pathways, especially NF-κB activity, in metastatic …

[HTML][HTML] Myeloid differentiation factor-2/LY96, a new predictive biomarker of metastasis in prostate cancer: Clinical implications as a potential therapeutic target

M Ferrari, L Wang, L Hoeppner, E Hahm, J Yu… - Research …, 2023 - ncbi.nlm.nih.gov
Relapsed prostate cancer (CaP), usually treated with androgen deprivation therapy,
acquires resistance to develop into lethal metastatic castration-resistant CaP. The cause of …

miR-503 靶向TLR4 对前列腺癌多西他赛耐药的影响

周舰, 张朝阳, 孙伟, 杨军, 张志超, 戚晓红 - 中国癌症杂志, 2020 - china-oncology.com
背景与目的: 在前列腺癌标准化疗方案中, 多西他赛(docetaxel, DTX) 引起的化疗耐药是引起
患者死亡的重要原因之一, 然而DTX 引起的化疗耐药相关机制尚未知. 探讨前列腺癌DTX …