RNA interference for multiple myeloma therapy: targeting signal transduction pathways
Introduction: Multiple myeloma (MM) is a hematological malignancy characterized by
infiltration of malignant plasma cells in the bone marrow (BM) and end-organ damage to the …
infiltration of malignant plasma cells in the bone marrow (BM) and end-organ damage to the …
METTL3 facilitates prostate cancer progression via inducing HOXC6 m6A modification and stabilizing its expression through IGF2BP2-dependent mechanisms
P He, X Liu, G Yu, Y Wang, S Wang, J Liu… - Molecular and Cellular …, 2024 - Springer
Abstract HOXC6 (Homeobox C6) and methyltransferase-like 3 (METTL3) have been shown
to be involved in the progression of prostate cancer (PCa). However, whether HOXC6 …
to be involved in the progression of prostate cancer (PCa). However, whether HOXC6 …
Nanoparticle based gene therapy approach: A pioneering rebellion in the management of psychiatric disorders
The neuropsychiatric illnesses have been enigmatic, with no effective treatment to date. The
complexity and heterogeneity of psychiatric disorders are daunting for the development of …
complexity and heterogeneity of psychiatric disorders are daunting for the development of …
[HTML][HTML] 合成生物学与纳米生物学的交叉融合及其在生物医药领域的应用
郑涵奇， 吴晴， 李洪军， 顾臻 - 合成生物学, 2022 - synbioj.cip.com.cn
合成生物学与纳米生物学的交叉融合业已成为促进生物技术与生物医药领域发展的重要方向之
一. 利用合成生物学技术可以帮助生物源性纳米材料创造特殊的结构与功能 …
一. 利用合成生物学技术可以帮助生物源性纳米材料创造特殊的结构与功能 …
A novel peptide for efficient siRNA delivery in vitro and therapeutics in vivo
R Pan, W Xu, F Yuan, D Chu, Y Ding, B Chen, M Jafari… - Acta biomaterialia, 2015 - Elsevier
Small interfering RNA (siRNA) shows great therapeutic potential due to its ability to regulate
gene expression in a highly selective manner. However, its application has been limited by …
gene expression in a highly selective manner. However, its application has been limited by …
[HTML][HTML] Nanocarriers: the promising future to cancer diagnostics and treatment
K Tapasya, AS Kumar… - Biomedical and …, 2022 - biomedpharmajournal.org
Nanotechnology recently gained attention for the novel and successful tools it has thus far
provided for cancer diagnosis and treatment. Some of them include lipid-based carriers such …
provided for cancer diagnosis and treatment. Some of them include lipid-based carriers such …
Design and evaluation of a stearylated multicomponent peptide-siRNA nanocomplex for efficient cellular siRNA delivery
Aim: To develop a new synthetic peptide-based nanoparticulate siRNA delivery system.
Materials & methods: DEN-K (GALA)-TAT-K (STR) was generated by incorporating stearic …
Materials & methods: DEN-K (GALA)-TAT-K (STR) was generated by incorporating stearic …
Personalized siRNA-nanoparticle systemic therapy using metastatic lymph node specimens obtained with EBUS-TBNA in lung cancer
Inhibiting specific gene expression with siRNA provides a new therapeutic strategy to tackle
many diseases at the molecular level. Recent strategies called high-density lipoprotein …
many diseases at the molecular level. Recent strategies called high-density lipoprotein …
[图书][B] Computational Materials, Chemistry, and Biochemistry: From Bold Initiatives to the Last Mile: In Honor of William A. Goddard's Contributions to Science and …
This book provides a broad and nuanced overview of the achievements and legacy of
Professor William (“Bill”) Goddard in the field of computational materials and molecular …
Professor William (“Bill”) Goddard in the field of computational materials and molecular …
Functionalised nanomaterials for eradication of CSCs, a promising approach for overcoming tumour heterogeneity
L Farahmand, B Darvishi, M Salehi… - Journal of Drug …, 2018 - Taylor & Francis
Today, intratumoural heterogeneity has been recognised as one of the main causes of
cancer treatment failure and drug resistance development through which multiple …
cancer treatment failure and drug resistance development through which multiple …