One of the most encountered obstacles for utilizing nano-sized vehicles to implement the in
vivo delivery of nucleic acid drugs (NADs) is the possible steric hindrance caused by their …

Oligonucleotide nanoparticles (ONPs) have been utilized as a small interfering RNA (siRNA)
delivery system because of their multiple advantages. However, the release of siRNA by …

pH-responsive diblock copolymers provide tailorable nanoparticle (NP) architecture and
chemistry critical for siRNA delivery. Here, diblock polymers varying in first (corona) and …

The functionality of DNA biomacromolecules has been widely excavated, as therapeutic
drugs, carriers, and functionalized modification derivatives. In this study, we developed a …

Small interfering RNAs (siRNA) have enormous potential as therapeutics to target and treat
various bone disorders such as osteoporosis and cancer bone metastases. However …

Tuberculosis (TB), caused by the infection of Mycobacterium tuberculosis (Mtb), continues to
pose a serious threat to public health, and the situation is worsening with the rapid …

Nanoparticles possess the ability to adsorb and load other compounds. This study aimed to
synthesize a gene carrier with polyethyleneimine (PEI), hyaluronic acid (HA) and …

Psoriasis is a chronic inflammatory disorder of the skin. Accumulating evidence indicates
that the Rel gene, a member of the NF-κB family, is a risk factor for the disease. We sought to …

Abstract siRNAs are very potent drug molecules, able to silence genes involved in
pathologies development. siRNAs have virtually an unlimited therapeutic potential …

Two of the most prominent challenges that limit the clinical success of siRNA therapies are a
lack of control over cargo release from the delivery vehicle and an incomplete …