Repurposing of antimycobacterium drugs for COVID-19 treatment by targeting SARS CoV-2 main protease: An in-silico perspective
A Chakraborty, R Ghosh, SS Mohapatra, S Barik… - Gene, 2024 - Elsevier
The global mortality rate has been significantly impacted by the COVID-19 pandemic,
caused by the SARS CoV-2 virus. Although the pursuit for a potent antiviral is still in …
caused by the SARS CoV-2 virus. Although the pursuit for a potent antiviral is still in …
What is the role of microbial biotechnology and genetic engineering in medicine?
F Santos‐Beneit - MicrobiologyOpen, 2024 - Wiley Online Library
Microbial products are essential for developing various therapeutic agents, including
antibiotics, anticancer drugs, vaccines, and therapeutic enzymes. Genetic engineering …
antibiotics, anticancer drugs, vaccines, and therapeutic enzymes. Genetic engineering …
Arylamines QSAR-Based Design and Molecular Dynamics of New Phenylthiophene and Benzimidazole Derivatives with Affinity for the C111, Y268, and H73 Sites of …
G Sabadini, M Mellado, C Morales, J Mella - Pharmaceuticals, 2024 - mdpi.com
A non-structural SARS-CoV-2 protein, PLpro, is involved in post-translational modifications
in cells, allowing the evasion of antiviral immune response mechanisms. In this study …
in cells, allowing the evasion of antiviral immune response mechanisms. In this study …
Unravelling Insights into the Evolution and Management of SARS-CoV-2
AGA Mushebenge, SC Ugbaja, NA Mbatha, RB Khan… - …, 2024 - mdpi.com
Worldwide, the COVID-19 pandemic, caused by the brand-new coronavirus SARS-CoV-2,
has claimed a sizable number of lives. The virus' rapid spread and impact on every facet of …
has claimed a sizable number of lives. The virus' rapid spread and impact on every facet of …
Quinazolines and thiazolidine-2, 4-dions as SARS-CoV-2 inhibitors: repurposing, in silico molecular docking and dynamics simulation
This paper presents an extensive analysis of COVID-19 with a specific focus on VEGFR-2
inhibitors as potential treatments. The investigation includes an overview of computational …
inhibitors as potential treatments. The investigation includes an overview of computational …
[HTML][HTML] Artificial intelligence for drug repurposing against infectious diseases
A Singh - Artificial Intelligence Chemistry, 2024 - Elsevier
Traditional drug discovery struggles to keep pace with the ever-evolving threat of infectious
diseases. New viruses and antibiotic-resistant bacteria, all demand rapid solutions. Artificial …
diseases. New viruses and antibiotic-resistant bacteria, all demand rapid solutions. Artificial …
RNA polymerase inhibitor enisamium for treatment of moderate COVID-19 patients: a randomized, placebo-controlled, multicenter, double-blind phase 3 clinical trial
O Holubovska, P Babich, A Mironenko, J Milde… - … in Respiratory Medicine, 2024 - mdpi.com
Highlights What are the main findings? Enisamium, administered in conjunction with
standard care, demonstrated clinical efficacy in hospitalized adults with moderate COVID-19 …
standard care, demonstrated clinical efficacy in hospitalized adults with moderate COVID-19 …