Congenital heart defects (CHDs) are the most prevalent and serious birth defect, occurring
in 1% of all live births. Pregestational maternal diabetes is a known risk factor for the …

Highlights•The similarities and differences between the mouse, human and non-human
primates (NHPs) in vitro embryo culture systems are compared.•Further optimization …

The third and fourth weeks of gestation in primates are marked by several developmental
milestones, including gastrulation and the formation of organ primordia. However, our …

Morphological phenotyping of the mouse embryo is described at neurulation stages,
primarily as a guide to evaluating the outcome of whole embryo cultures between embryonic …

Background The increasing population of diabetes mellitus in adolescent girls and women
of childbearing age contributes to a large number of pregnancies with maternal …

CreERT2‐mediated gene recombination is widely applied in developmental biology
research. Activation of CreERT2 is typically achieved by injection of tamoxifen in an oily …

Background Cannabidiol (CBD) is a nonpsychoactive constituent of cannabis widely
available as a dietary supplement. Previous reports that it impairs the retinoid, sonic …

A wide range of cancers throughout the body are characterized by high nerve density and
invasion of cancer cells within the nerves, a process called perineural invasion (PNI). Work …

Background Sex differences in disease frequency and severity are common. Although they
can result from sex hormone influence, a gender bias in birth defects often arises before the …