Central nervous system (CNS) disorders (eg, multiple sclerosis, Alzheimer's disease, etc.)
represent a growing public health issue, primarily due to the increased life expectancy and …

Cholesterol is an indispensable component of the cell membrane and plays vital roles in
critical physiological processes. Brain cholesterol accounts for a large portion of total …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that results from
many diverse genetic causes. Although therapeutics specifically targeting known causal …

Prion diseases are progressive, incurable and fatal neurodegenerative conditions. The term
'prion'was first nominated to express the revolutionary concept that a protein could be …

Oxidative stress emerges as a critical mechanism underlying the development and
progression of various brain diseases, arising from either increased generation of reactive …

Neurodegenerative disorders (NDs) affect essential functions not only in the CNS, but also
cause persistent gut dysfunctions, suggesting that they have an impact on both CNS and gut …

In recent years, the inter-relationship between the innate immune system and the central
nervous system (CNS) has moved to the forefront of biomedical research, with the discovery …

Fibrillar protein aggregates are characteristic of neurodegenerative diseases but represent
difficult targets for ligand design, because limited structural information about the binding …

Neurodegenerative diseases are a heterogeneous group of maladies, characterized by
progressive loss of neurons. These diseases involve an intricate pattern of cross-talk …

Cells rely on stress response pathways to uphold cellular homeostasis and limit the negative
effects of harmful environmental stimuli. The stress-and mitogen-activated protein (MAP) …