Neuroinflammation is a well-characterized pathophysiology occurring in association with the
progression of Parkinson's disease. Characterizing the cellular and molecular basis of …

Cell death in human diseases is often a consequence of disrupted cellular homeostasis. If
cell death is prevented without restoring cellular homeostasis, it may lead to a persistent …

One of the hallmark features in the neurodegenerative disorders (NDDs) is the accumulation
of aggregated and/or non-functional protein in the cellular milieu. Post-translational …

Since the mid-20th century, Western societies have considered productivity and economic
outcomes are more important than focusing on people's health and wellbeing. This focus …

The nervous system plays a critical role in maintaining whole-organism homeostasis;
neurons experiencing mitochondrial stress can coordinate the induction of protective cellular …

Spirulina is a microscopic, filamentous cyanobacterium that grows in alkaline water bodies.
It is extensively utilized as a nutraceutical food supplement all over the world due to its high …

Neurodegenerative diseases are characterized by a progressive loss of neurons in the brain
or spinal cord that leads to a loss of function of the affected areas. The lack of effective …

Many neurodegenerative disorders, including Parkinson's, Alzheimer's, and amyotrophic
lateral sclerosis, are well known to involve the accumulation of disease-specific proteins …

Protein aggregates are formed in cells with profoundly perturbed proteostasis, where the
generation of misfolded proteins exceeds the cellular refolding and degradative capacity …

Background Amyotrophic lateral sclerosis (ALS) associated with TAR DNA-binding protein
43 (TDP-43) aggregation has been considered as a lethal and progressive motor neuron …