Many proteins in the cell fold cotranslationally within the restricted space of the polypeptide
exit tunnel or at the surface of the ribosome. A growing body of evidence suggests that the …

Aging is a crucial risk factor for common neurodegenerative diseases, such as Alzheimer's
disease (AD) and Parkinson's disease (PD). Limited options are available for the treatment …

Activation of the NLRP3 inflammasome and its mediated neuroinflammation are implicated
in neurodegenerative diseases, while mitophagy negatively regulates NLRP3 …

Gene therapy is an emerging and powerful therapeutic tool to deliver functional genetic
material to cells in order to correct a defective gene. During the past decades, several …

Neurodegenerative diseases (NDs) represent a heterogeneous group of aging-related
disorders featured by progressive impairment of motor and/or cognitive functions, often …

Increased understanding of intrinsically disordered proteins (IDPs) and protein regions has
revolutionized our view of the relationship between protein structure and function. Data now …

Protein function and flexibility is directly related to the native distribution of its structural
elements and any alteration in protein architecture leads to several abnormalities and …

NRF2 acts by controlling gene expression, being the master regulator of the Phase II
antioxidant response, and also being key to the control of neuroinflammation. NRF2 activity …

Transcription factors play vital roles in neuron development; however, little is known about
the role of these proteins in maintaining neuronal homeostasis. Here, we show that the …

Palm oil is rich in tocotrienols (T3s), a type of vitamin E that has garnered considerable
research interest as it exhibits anti-inflammatory as well as antioxidant characteristics that …