Emerging neuroprotective strategies for the treatment of ischemic stroke: An overview of clinical and preclinical studies
S Paul, E Candelario-Jalil - Experimental neurology, 2021 - Elsevier
Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …
With the global population aged 65 and over growing faster than all other age groups, the …
[HTML][HTML] Ischemia-reperfusion injury: molecular mechanisms and therapeutic targets
Abstract Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following
ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate …
ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate …
Remote ischaemic conditioning—a new paradigm of self-protection in the brain
DC Hess, RA Blauenfeldt, G Andersen… - Nature Reviews …, 2015 - nature.com
Remote ischaemic conditioning (RIC) triggers endogenous protective pathways in distant
organs such as the kidney, heart and brain, and represents an exciting new paradigm in …
organs such as the kidney, heart and brain, and represents an exciting new paradigm in …
[HTML][HTML] Blood pressure and penumbral sustenance in stroke from large vessel occlusion
RW Regenhardt, AS Das, CJ Stapleton… - Frontiers in …, 2017 - frontiersin.org
The global burden of stroke remains high, and of the various subtypes of stroke, large vessel
occlusions (LVOs) account for the largest proportion of stroke-related death and disability …
occlusions (LVOs) account for the largest proportion of stroke-related death and disability …
[HTML][HTML] Neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injury are associated with inhibition of pro-inflammatory mediator production and …
M Jiang, J Li, Q Peng, Y Liu, W Liu, C Luo… - Journal of …, 2014 - Springer
Background Mitogen-activated protein kinase (MAPK) signaling pathways are implicated in
inflammatory and apoptotic processes of cerebral ischemia and reperfusion (I/R) injury …
inflammatory and apoptotic processes of cerebral ischemia and reperfusion (I/R) injury …
[HTML][HTML] Glucagon-like peptide-1 (GLP-1) receptor activation dilates cerebral arterioles, increases cerebral blood flow, and mediates remote (pre) conditioning …
Stroke remains one of the most common causes of death and disability worldwide. Several
preclinical studies demonstrated that the brain can be effectively protected against …
preclinical studies demonstrated that the brain can be effectively protected against …
Protection of organs other than the heart by remote ischemic conditioning
L Candilio, A Malik, DJ Hausenloy - Journal of cardiovascular …, 2013 - journals.lww.com
Organ or tissue dysfunction due to acute ischemia–reperfusion injury (IRI) is the leading
cause of death and disability worldwide. Acute IRI induces cell injury and death in a wide …
cause of death and disability worldwide. Acute IRI induces cell injury and death in a wide …
[HTML][HTML] Limb remote ischemic conditioning: mechanisms, anesthetics, and the potential for expanding therapeutic options
G Chen, M Thakkar, C Robinson, S Doré - Frontiers in neurology, 2018 - frontiersin.org
Novel and innovative approaches are essential in developing new treatments and improving
clinical outcomes in patients with ischemic stroke. Remote ischemic conditioning (RIC) is a …
clinical outcomes in patients with ischemic stroke. Remote ischemic conditioning (RIC) is a …
[HTML][HTML] Remote ischemic conditioning: a promising therapeutic intervention for multi-organ protection
D Zhou, J Ding, J Ya, L Pan, Y Wang, X Ji… - Aging (Albany NY …, 2018 - ncbi.nlm.nih.gov
Despite decades of formidable exploration, multi-organ ischemia-reperfusion injury (IRI)
encountered, particularly amongst elderly patients with clinical scenarios, such as age …
encountered, particularly amongst elderly patients with clinical scenarios, such as age …
Remote limb perconditioning and postconditioning: will it translate into a promising treatment for acute stroke?
These preclinical findings launched a number of randomized clinical trials of remote limb
preconditioning to protect the heart. In a meta-analysis of 23 randomized clinical trials of …
preconditioning to protect the heart. In a meta-analysis of 23 randomized clinical trials of …