Stroke is the leading cause of disability and thesecond leading cause of death worldwide.
With the global population aged 65 and over growing faster than all other age groups, the …

Abstract Ischemia-reperfusion (I/R) injury paradoxically occurs during reperfusion following
ischemia, exacerbating the initial tissue damage. The limited understanding of the intricate …

Remote ischaemic conditioning (RIC) triggers endogenous protective pathways in distant
organs such as the kidney, heart and brain, and represents an exciting new paradigm in …

The global burden of stroke remains high, and of the various subtypes of stroke, large vessel
occlusions (LVOs) account for the largest proportion of stroke-related death and disability …

Background Mitogen-activated protein kinase (MAPK) signaling pathways are implicated in
inflammatory and apoptotic processes of cerebral ischemia and reperfusion (I/R) injury …

Stroke remains one of the most common causes of death and disability worldwide. Several
preclinical studies demonstrated that the brain can be effectively protected against …

Organ or tissue dysfunction due to acute ischemia–reperfusion injury (IRI) is the leading
cause of death and disability worldwide. Acute IRI induces cell injury and death in a wide …

Novel and innovative approaches are essential in developing new treatments and improving
clinical outcomes in patients with ischemic stroke. Remote ischemic conditioning (RIC) is a …

Despite decades of formidable exploration, multi-organ ischemia-reperfusion injury (IRI)
encountered, particularly amongst elderly patients with clinical scenarios, such as age …

These preclinical findings launched a number of randomized clinical trials of remote limb
preconditioning to protect the heart. In a meta-analysis of 23 randomized clinical trials of …