While the Staudinger reaction has first been described a hundred years ago in 1919, the
ligation reaction became one of the most important and efficient bioconjugation techniques …

This review aims at answering the following question: how can a researcher be sure to
succeed in grafting a protein onto a polymer surface? Even if protein immobilization on solid …

A cure for type 1 diabetes (T1D) would help millions of people worldwide but remains
elusive to date. Tolerogenic vaccines and β-cell replacement therapy are complementary …

Allogeneic islet transplantation is a promising cell-based therapy for Type 1 Diabetes (T1D).
The long-term efficacy of this approach, however, is impaired by allorejection. Current …

Cancer is a devastating disease and the primary cause of morbidity and mortality worldwide,
with cancer metastasis responsible for 90% of cancer-related deaths. Cancer metastasis is a …

Thanks to impressive technology advancements, pervasive expression of non-coding RNAs
(ncRNAs) has been recently identified in the genome of numerous cancers. Long ncRNAs …

Immune homeostasis is maintained by a precise balance between effector immune cells and
regulatory immune cells. Chronic deviations from immune homeostasis, driven by a greater …

Immunotherapy has been widely explored for applications to both augment and suppress
intrinsic host immunity. Clinical achievements have seen a number of immunotherapeutic …

Regulatory T cell (Treg)-based therapeutics are receiving increased attention for their
potential to treat autoimmune disease and prevent transplant rejection. Adoptively …

Although transplantation of pancreatic islets is a promising approach for treatment of type 1
diabetes mellitus, the engraftment efficiency of these islets is limited by host immune …