Type 2 diabetes is a metabolic, chronic disorder characterized by insulin resistance and
elevated blood glucose levels. Although a large drug portfolio exists to keep the blood …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

Isolated reports of new-onset diabetes in individuals with COVID-19 have led to the
hypothesis that SARS-CoV-2 is directly cytotoxic to pancreatic islet β cells. This would …

Diabetes is a global public health burden and is characterized clinically by relative or
absolute insulin deficiency. Therapeutic agents that stimulate insulin secretion and improve …

Quantification of insulin is essential for diabetes research in general, and for the study of
pancreatic β‐cell function in particular. Herein, fluorescent single‐walled carbon nanotubes …

Type 1 diabetes is characterised by autoimmune-mediated destruction of pancreatic β-cell
mass. With the advent of insulin therapy a century ago, type 1 diabetes changed from a …

Insulin-producing β-cells constitute the majority of the cells in the pancreatic islets.
Dysfunction of these cells is a key factor in the loss of glucose regulation that characterizes …

Pancreatic islets are highly interconnected structures that produce pulses of insulin and
other hormones, maintaining normal homeostasis of glucose and other nutrients. Normal …

Abstract β-Cells depend on the islet basement membrane (BM). While some islet BM
components are produced by endothelial cells (ECs), the source of others remains …

Many details of glucose-stimulated intracellular calcium changes in β cells during activation,
activity, and deactivation, as well as their concentration-dependence, remain to be analyzed …