The physiology and pathophysiology of the exocrine pancreas are in close connection to
changes in intra-cellular Ca2+ concentration. Most of our knowledge is based on in vitro …

Diabetes of the exocrine pancreas (DEP), also commonly described as pancreatogenic
diabetes mellitus, is a type of diabetes secondary to abnormalities in pancreatic or exocrine …

Diabetes is not only an endocrine but also a vascular disease. Vascular defects are usually
seen as consequence of diabetes. However, at the level of the pancreatic islet, vascular …

RNA binding protein HuD plays essential roles in gene expression by regulating RNA
metabolism, and its dysregulation is involved in the pathogenesis of several diseases …

Type 2 diabetes mellitus (T2DM) is a complex and heterogeneous metabolic disorder
characterized by the damage and eventual loss of pancreatic β cells resulting in abnormal …

Type-1-diabetes (T1D) is a multifactorial disorder with a global incidence of about 8.4 million
individuals in 2021. It is primarily classified as an autoimmune disorder, where the …

The first recognition of the pancreas as an organ is accredited to Herophilus of Chalcedon,
often called the father of anatomy, more than 2000 years ago [1]. The functions of the organ …

Introduction Type 1 diabetes mellitus (T1DM) development involves a complex interplay of
genetic, environmental, and immunological factors. By modulating the activity of proteases …

Introduction Immune cells were recently shown to support β-cells and insulin secretion.
However, little is known about how islet immune cells are regulated to maintain glucose …

Tafazzin (TAZ) is a cardiolipin (CL) biosynthetic enzyme important for maintaining
mitochondrial function. TAZ affects both the species and content of CL in the inner …