The pancreatic islet depends on blood supply to efficiently sense plasma glucose levels and
deliver insulin and glucagon into the circulation. Long thought to be passive conduits of …

Islet transplantation is a promising treatment for type 1 diabetes (T1D), but limited islet
engraftment hampers its success. In vivo, islets require time to remodel the hepatic …

Diabetes is a global public health burden and is characterized clinically by a relative or
absolute insulin deficiency. Therapeutic agents that stimulate and improve insulin secretion …

The pancreas, a crucial organ of the endocrine system, is structurally organized in the islets
of Langerhans. The islet microenvironment, comprising mesenchymal, vascular endothelial …

Glucose progressively stimulates insulin release over a wide range of concentrations.
However, the nutrient coding underlying activation, activity, and deactivation of beta cells …

Pancreatic islets are central in the control of blood glucose and their dysfunction is a
hallmark of diabetes. Incomplete knowledge of islet biology currently prevents diagnostic …

Aim: Exercise is a type of non-pharmacological treatment for obesity and type 2 diabetes,
and at the same time, the molecular mechanisms responsible for genetic adaptations to it …

Objective Tafazzin (TAZ) is a cardiolipin (CL) biosynthetic enzyme important for maintaining
mitochondrial function. TAZ impacts both the species and content of CL in the inner …

O HNF4αé um fator de transcrição importante para a regulação da capacidade das células
β de secretar insulina adequadamente em resposta a concentração de glicose. Sabe-se …

Glucose homeostasis in the body is maintained by highly vascularized microorganisms in
the pancreas. Insulin secretion from beta cells is dependent on the presence of healthy islet …