The mammalian bromodomain and extra-terminal domain (BET) family of proteins consists
of four conserved members (Brd2, Brd3, Brd4, and Brdt) that regulate numerous cancer …

The nuclear factor erythroid 2 (NF-E2)-related factor 1 (NFE2L1, also known as Nrf1) is a
highly conserved transcription factor that belongs to the CNC-bZIP subfamily. Its significance …

Proteasome machinery is a major proteostasis control system in human cells, actively
compensated upon its inhibition. To understand this compensation, we compared global …

Chiral drugs usually contain chiral centers, which are present as single enantiomers or
racemates. Compared with achiral drugs, they have significant advantages in safety and …

Simple Summary In the last decade, proteasome inhibitors (PIs) have become a standard for
the treatment of multiple myeloma (MM). As a consequence of the pleiotropic effects of PIs …

Small cell lung cancer (SCLC) is a recalcitrant malignancy with limited treatment options.
Bromodomain and extraterminal domain inhibitors (BETis) have shown promising preclinical …

The key to a healthy mammalian cell lies in properly functioning proteolytic machineries
called proteasomes. The proteasomes are multisubunit complexes that catalyze the …

Cells exposed to proteotoxic stress invoke adaptive responses aimed at restoring
proteostasis. Our previous studies have established a firm role for the transcription factor …

Multiple myeloma (MM) treatment regimens have vastly improved since the introduction of
immunomodulators, proteasome inhibitors, and anti-CD38 monoclonal antibodies; however …

Background Medulloblastoma is the most common malignant pediatric brain tumor and
group 3 subtype medulloblastoma (G3-MB) exhibits the worst prognosis. Super enhancers …