Metabolomics: small molecules that matter more

BC Muthubharathi, T Gowripriya, K Balamurugan - Molecular omics, 2021 - pubs.rsc.org
Metabolomics, an analytical study with high-throughput profiling, helps to understand
interactions within a biological system. Small molecules, called metabolites or metabolomes …

The role of vitamins in neurodegenerative disease: An update

SN Rai, P Singh, HWM Steinbusch, E Vamanu… - Biomedicines, 2021 - mdpi.com
Acquiring the recommended daily allowance of vitamins is crucial for maintaining
homeostatic balance in humans and other animals. A deficiency in or dysregulation of …

Gut microbiota and metabolome alterations associated with Parkinson's disease

S Vascellari, V Palmas, M Melis, S Pisanu, R Cusano… - Msystems, 2020 - Am Soc Microbiol
Parkinson's disease is a neurodegenerative disorder characterized by the accumulation of
intracellular aggregates of misfolded alpha-synuclein along the cerebral axis. Several …

[HTML][HTML] ESPEN micronutrient guideline

MM Berger, A Shenkin, A Schweinlin, K Amrein… - Clinical Nutrition, 2022 - Elsevier
Background Trace elements and vitamins, named together micronutrients (MNs), are
essential for human metabolism. Recent research has shown the importance of MNs in …

Cerebral deficiency of vitamin B5 (d-pantothenic acid; pantothenate) as a potentially-reversible cause of neurodegeneration and dementia in sporadic Alzheimer's …

J Xu, S Patassini, P Begley, S Church… - Biochemical and …, 2020 - Elsevier
Alzheimer's disease (AD) is the most common cause of age-related neurodegeneration and
dementia, and there are no available treatments with proven disease-modifying actions. It is …

The pathophysiological role of CoA

A Czumaj, S Szrok-Jurga, A Hebanowska… - International Journal of …, 2020 - mdpi.com
The importance of coenzyme A (CoA) as a carrier of acyl residues in cell metabolism is well
understood. Coenzyme A participates in more than 100 different catabolic and anabolic …

Gut microbiota-derived vitamins–underrated powers of a multipotent ally in psychiatric health and disease

L Rudzki, TW Stone, M Maes, B Misiak… - Progress in Neuro …, 2021 - Elsevier
Despite the well-established roles of B-vitamins and their deficiencies in health and disease,
there is growing evidence indicating a key role of those nutrients in functions of the central …

Immunoassays for the rapid detection of pantothenic acid in pharmaceutical and food products

L Zeng, L Guo, Z Wang, X Xu, S Song, L Xu, H Kuang… - Food Chemistry, 2021 - Elsevier
Pharmaceutical and food products are fortified with pantothenic acid (PA) to address
potential deficiency. Therefore, its fast, reliable, and accurate detection is of great …

UPLC-MS-based urine nontargeted metabolic profiling identifies dysregulation of pantothenate and CoA biosynthesis pathway in diabetic kidney disease

T Ma, T Liu, P Xie, S Jiang, W Yi, P Dai, X Guo - Life sciences, 2020 - Elsevier
Aims Diabetic kidney disease (DKD) is a major prevalent chronic microvascular
complication of type 2 diabetes (T2D). However, the present diagnostic indicators have …

Multi-regional alterations in glucose and purine metabolic pathways in the Parkinson's disease dementia brain

M Scholefield, SJ Church, G Taylor, D Knight… - npj Parkinson's …, 2023 - nature.com
Parkinson's disease (PD) is one of the most common neurodegenerative diseases, most
commonly characterised by motor dysfunction, but also with a high prevalence of cognitive …