Brown adipose tissue (BAT) displays the unique capacity to generate heat through
uncoupled oxidative phosphorylation that makes it a very attractive therapeutic target for …

Metabolic anomalies contribute to tissue dysfunction. Current metabolism research spans
from organelles to populations, and new technologies can accommodate investigation …

Preoperative MRI is one of the most important clinical results for the diagnosis and treatment
of glioma patients. The objective of this study was to construct a stable and validatable …

Purpose To present first highly spatially resolved deuterium metabolic imaging (DMI)
measurements of the human brain acquired with a dedicated coil design and a fast chemical …

Deuterium metabolic spectroscopy (DMS) and imaging (DMI) have recently been described
as simple and robust MR-based methods to map metabolism with high temporal and/or …

Background Tumor cells frequently show high rates of aerobic glycolysis, which provides the
glycolytic intermediates needed for the increased biosynthetic demands of rapid cell growth …

Over more than 30 years in vivo MR spectroscopic imaging (MRSI) has undergone an
enormous evolution from theoretical concepts in the early 1980s to the robust imaging …

Deuterium metabolic imaging (DMI) and hyperpolarized 13 C-pyruvate MRI (13 C-HPMRI)
are two emerging methods for non-invasive and non-ionizing imaging of tissue metabolism …

Hydrogen isotope exchange (HIE) has become one of the most studied methods to prepare
deuterated molecules, with the primary focus recently on metal-catalyzed C–H activation …

Ultrahigh magnetic fields offer significantly higher signal-to-noise ratio, and several
magnetic resonance applications additionally benefit from a higher contrast-to-noise ratio …