The microvascular endothelium serves as the major barrier that controls the transport of
blood constituents across the vessel wall. Barrier leakage occurs during infection or sterile …

Systemic inflammatory response syndrome (SIRS) is a non-specific exaggerated defense
response caused by infectious or non-infectious stressors such as trauma, burn, surgery …

Morphological and physiological changes in the vasculature have been described in the
evolution and maintenance of hypertension. Hypertension-induced vascular dysfunction …

Effective treatment for managing myocardial infarction (MI) remains an urgent, unmet clinical
need. Formyl peptide receptors (FPR) regulate inflammation, a major contributing …

Uncontrolled immune system activation amplifies end-organ injury in hypertension.
Nonetheless, the exact mechanisms initiating this exacerbated inflammatory response …

Sepsis is defined as a life‐threatening organ dysfunction caused by a dysregulated host
response to infection. It remains a leading cause of death worldwide, despite the …

The recent emergence of severe acute respiratory syndrome-Corona Virus 2 (SARS-CoV-2)
in late 2019 and its spread worldwide caused an acute pandemic of Coronavirus disease 19 …

Mitochondria are key organelles of cellular energy metabolism; both mitochondrial function
and metabolism determine the physiological function of cells and serve an essential role in …

Background Acute respiratory distress syndrome (ARDS) is an often fatal neutrophil-
dominant lung disease. Although influenced by multiple proinflammatory mediators …

Atherosclerosis results in life-threatening cardiovascular pathologies, including ischemic
heart disease, stroke, myocardial infarction, and peripheral arterial disease. The role of …