Acute kidney injury is common in patients with liver disease and associated with significant
morbidity and mortality. Besides bacterial infections, fluid loss, and use of nephrotoxic drugs …

Significance: Sepsis is a major public health concern, with high mortality and morbidity,
especially among patients undergoing trauma. It is characterized by a systemic inflammatory …

Background The blood‐brain barrier (BBB) is critical for cerebrovascular health. Although
aging impairs the integrity of the BBB, the mechanisms behind this phenomenon are not …

Acute kidney injury (AKI) is a systemic inflammatory disease that contributes to remote organ
failures. Multiple organ failure is the leading cause of death due to AKI, and lack of …

Regulated cell death is an essential and heterogeneous process occurring in the life cycle of
organisms, from embryonic development and aging to the regulation of homeostasis and …

Endothelium, the gatekeeper of our blood vessels, is highly heterogeneous and a crucial
physical barrier with the ability to produce vasoactive and protective mediators under …

BACKGROUND Platelet concentrates (PCs) are the most common blood components
eliciting nonhemolytic transfusion reactions (NHTRs), such as allergic transfusion reactions …

Insufficient autophagy has been proposed as a mechanism of cellular aging, as this leads to
the accumulation of dysfunctional macromolecules and organelles. Premature vascular …

Renal dysfunction is prevalent in patients with advanced cirrhosis and decompensation. The
presence of type 1 hepatorenal syndrome (HRS) has traditionally been defined by a set of …

Background: Formyl peptide receptor 2 (FPR2) is involved in the pathogenesis of chronic
inflammatory diseases, being activated either by pro-resolving or proinflammatory ligands …