[HTML][HTML] Formyl peptide receptor activation elicits endothelial cell contraction and vascular leakage
CF Wenceslau, CG McCarthy, RC Webb - Frontiers in immunology, 2016 - frontiersin.org
The major pathophysiological characteristic of systemic inflammatory response syndrome
(SIRS) and sepsis is the loss of control of vascular tone and endothelial barrier dysfunction …
(SIRS) and sepsis is the loss of control of vascular tone and endothelial barrier dysfunction …
[HTML][HTML] Honokiol suppresses formyl peptide-induced human neutrophil activation by blocking formyl peptide receptor 1
FC Liu, HP Yu, YT Syu, JY Fang, CF Lin, SH Chang… - Scientific reports, 2017 - nature.com
Abstract Formyl peptide receptor 1 (FPR1) mediates bacterial and mitochondrial N-formyl
peptides-induced neutrophil activation. Therefore, FPR1 is an important therapeutic target …
peptides-induced neutrophil activation. Therefore, FPR1 is an important therapeutic target …
Mitochondrial damage-associated molecular patterns exacerbate lung fluid imbalance via the formyl peptide receptor-1 signaling pathway in acute lung injury
Z Yuan, N Zeng, L Liu, T Wang, L Dai… - Critical care …, 2021 - journals.lww.com
OBJECTIVES: To investigate the effect of mitochondrial damage–associated molecular
patterns on the lung fluid homeostasis in experimental acute lung injury. DESIGN …
patterns on the lung fluid homeostasis in experimental acute lung injury. DESIGN …
[HTML][HTML] The Yin and Yang of alarmins in regulation of acute kidney injury
V Sabapathy, R Venkatadri, M Dogan… - Frontiers in Medicine, 2020 - frontiersin.org
Acute kidney injury (AKI) is a major clinical burden affecting 20 to 50% of hospitalized and
intensive care patients. Irrespective of the initiating factors, the immune system plays a major …
intensive care patients. Irrespective of the initiating factors, the immune system plays a major …
[HTML][HTML] Garcinia multiflora inhibits FPR1-mediated neutrophil activation and protects against acute lung injury
YF Tsai, SC Yang, WY Chang, JJ Chen… - Cellular Physiology and …, 2019 - karger.com
Background/Aims: Formyl peptide receptors (FPRs) recognize different endogenous and
exogenous molecular stimuli and mediate neutrophil activation. Dysregulation of excessive …
exogenous molecular stimuli and mediate neutrophil activation. Dysregulation of excessive …
[HTML][HTML] Targeting endothelial barrier dysfunction caused by circulating bacterial and mitochondrial N-formyl peptides with deformylase
P Martinez-Quinones, A Komic, CG McCarthy… - Frontiers in …, 2019 - frontiersin.org
Despite recent advances in our understanding of the mechanisms underlying systemic
inflammatory response syndrome (SIRS) and sepsis, the current therapeutic approach to …
inflammatory response syndrome (SIRS) and sepsis, the current therapeutic approach to …
Ethanol: striking the cardiovascular system by harming the gut microbiota
CBP Silva, J Elias-Oliveira… - American Journal …, 2021 - journals.physiology.org
Ethanol consumption represents a significant public health problem, and excessive ethanol
intake is a risk factor for cardiovascular disease (CVD), one of the leading causes of death …
intake is a risk factor for cardiovascular disease (CVD), one of the leading causes of death …
[HTML][HTML] Chronic lung allograft dysfunction is associated with increased levels of cell-free mitochondrial DNA in bronchoalveolar lavage fluid of lung transplant …
E Schneck, I Askevold, R Rath, A Hecker… - Journal of Clinical …, 2022 - mdpi.com
Chronic Lung Allograft Dysfunction (CLAD) is a life-threatening complication that limits the
long-term survival of lung transplantation patients. Early diagnosis remains the basis of …
long-term survival of lung transplantation patients. Early diagnosis remains the basis of …
[HTML][HTML] Mitocryptide-2: Identification of Its Minimum Structure for Specific Activation of FPR2–Possible Receptor Switching from FPR2 to FPR1 by Its Physiological C …
T Marutani, K Nishino, T Miyaji, K Kamada… - International Journal of …, 2021 - mdpi.com
Mitocryptides are a novel family of endogenous neutrophil-activating peptides originating
from various mitochondrial proteins. Mitocryptide-2 (MCT-2) is one of such neutrophil …
from various mitochondrial proteins. Mitocryptide-2 (MCT-2) is one of such neutrophil …
Peritoneal cavity lavage reduces the presence of mitochondrial damage associated molecular patterns in open abdomen patients
PA Martinez-Quinones, CG McCarthy… - Journal of Trauma …, 2017 - journals.lww.com
BACKGROUND Mitochondrial damage-associated molecular patterns (mtDAMPs), such as
mitochondrial DNA and N-formylated peptides, are endogenous molecules released from …
mitochondrial DNA and N-formylated peptides, are endogenous molecules released from …