Computational imaging and quantitative biomarkers offer invaluable insights in the pre-
symptomatic phase of neurodegenerative conditions several years before clinical …

Background Frontotemporal dementia (FTD) phenotypes are classically associated with
distinctive cortical atrophy patterns and regional hypometabolism. However, the spectrum of …

Background: Magnetic resonance spectroscopy (MRS) in amyotrophic lateral sclerosis
(ALS) has been overwhelmingly applied to motor regions to date and our understanding of …

Introduction Hereditary spastic paraplegias (HSP) include a clinically and genetically
heterogeneous group of conditions. Novel imaging modalities have been increasingly …

Currently, there is an urgent need to better comprehend neuroplastic alterations in
cannabinoid receptors type 1 (CB1) and to understand the biological meaning of these …

Background Primary lateral sclerosis (PLS) is traditionally regarded as a pure upper motor
neuron disorder, but recent cases series have highlighted cognitive deficits in executive and …

Despite the universal recognition of the fundamental clinical, genetic and pathological
heterogeneity of amyotrophic lateral sclerosis (ALS), the expectation that the same drug may …

Abstract Objective The Corona Radiata (CR) is a large white matter tract in the brain
comprising of the anterior CR (aCR), superior CR (sCR), and posterior CR (pCR), which …

Background Language deficits are cardinal manifestations of some frontotemporal dementia
(FTD) phenotypes and also increasingly recognized in sporadic and familial amyotrophic …

The arrival of genotype-specific therapies in amyotrophic lateral sclerosis (ALS) signals the
dawn of precision medicine in motor neuron diseases (MNDs). After decades of academic …