OA is a degenerative joint disease characterized by articular cartilage degradation,
osteophyte formation, synovitis, and subchondral bone sclerosis. One of OAs main risk …

Osteoarthritis is a common, progressive joint disease, and treatments generally aim for
symptomatic improvement. However, SYmptomatic Slow-Acting Drugs in Osteoarthritis …

Over the past few decades, significant progress has been made with respect to new
concepts about the pathogenesis of osteoarthritis (OA). This article summarises some of the …

The objective of this study was to identify, on a symptomatic knee osteoarthritis (OA) cohort,
the risk factors associated with the progression of the disease. More specifically, we …

Osteoarthritis (OA) is a progressive and disabling disease resulting from a combination of
risk factors, including advancing age, genetics, trauma, knee malalignment, increased …

Osteoarthritis is a chronic disease characterised by irreversible damage to joint structures,
including loss of articular cartilage, osteophyte formation, alterations in the subchondral …

Osteoarthritis (OA) is a disease of the joints that affects several million individuals worldwide.
This disease, which involves mainly the diarthrodial joints, is chronic and develops slowly …

Objectives. Earlier studies suggest the involvement of osteoprotegerin (OPG), RANK and
RANK ligand (RANKL) in OA subchondral bone metabolism; however, few studies have …

INTRODUCTION: In osteoarthritis (OA) the progression of cartilage degeneration has been
associated with remodeling of the subchondral bone. Human OA subchondral bone …

Early in the pathological process of osteoarthritis (OA), subchondral bone remodelling,
which is related to altered osteoblast metabolism, takes place. In the present study, we …