Targetable elements in SARS-CoV-2 S2 subunit for the design of pan-coronavirus fusion inhibitors and vaccines

L Guo, S Lin, Z Chen, Y Cao, B He, G Lu - Signal Transduction and …, 2023 - nature.com
The ongoing global pandemic of coronavirus disease 2019 (COVID-19), caused by severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has caused devastating impacts …

COVID-19-related health outcomes in people with primary immunodeficiency: A systematic review

E Drzymalla, RF Green, M Knuth, MJ Khoury… - Clinical …, 2022 - Elsevier
A better understanding of COVID-19 in people with primary immunodeficiency (PI), rare
inherited defects in the immune system, is important for protecting this population, especially …

SARS-CoV-2 vaccine induced atypical immune responses in antibody defects: everybody does their best

AF Salinas, EP Mortari, S Terreri, C Quintarelli… - Journal of clinical …, 2021 - Springer
Background Data on immune responses to SARS-CoV-2 in patients with Primary Antibody
Deficiencies (PAD) are limited to infected patients and to heterogeneous cohorts after …

Coronavirus disease 2019 in patients with inborn errors of immunity: lessons learned

G Bucciol, SG Tangye, I Meyts - Current opinion in pediatrics, 2021 - journals.lww.com
We review the characteristics of SARS-CoV-2 infection in a large number of patients with IEI.
Overall, we found that combined immunodeficiencies, immune dysregulation disorders, and …

B cell response induced by SARS-CoV-2 infection is boosted by the BNT162b2 vaccine in primary antibody deficiencies

F Pulvirenti, A Fernandez Salinas, C Milito, S Terreri… - Cells, 2021 - mdpi.com
Background: Patients with primary antibody deficiencies are at risk in the current COVID-19
pandemic due to their impaired response to infection and vaccination. Specifically, patients …

COVID-19 and inborn errors of immunity

OM Delmonte, R Castagnoli, LD Notarangelo - Physiology, 2022 - journals.physiology.org
Inborn errors of immunity (IEI) are a heterogeneous group of disorders affecting immune
host defense and immunoregulation. Considering the predisposition to develop severe and …

Covid-19 in patients with chronic lymphocytic leukemia: clinical outcome and B-and T-cell immunity during 13 months in consecutive patients

L Blixt, G Bogdanovic, M Buggert, Y Gao, S Hober… - Leukemia, 2022 - nature.com
We studied clinical and immunological outcome of Covid-19 in consecutive CLL patients
from a well-defined area during month 1–13 of the pandemic. Sixty patients (median age 71 …

SARS-CoV-2 T cell response in severe and fatal COVID-19 in primary antibody deficiency patients without specific humoral immunity

S Steiner, T Schwarz, VM Corman, L Gebert… - Frontiers in …, 2022 - frontiersin.org
Morbidity and mortality of COVID-19 is increased in patients with inborn errors of immunity
(IEI). Age and comorbidities and also impaired type I interferon immunity were identified as …

Duration of immunity to SARS-CoV-2 in children after natural infection or vaccination in the omicron and pre-omicron era: A systematic review of clinical and …

D Buonsenso, F Cusenza, L Passadore… - Frontiers in …, 2023 - frontiersin.org
Background Duration of humoral and cellular memory in children previously infected SARS-
CoV-2 or vaccinated and subsequent risk of reinfection is still not fully elucidated. Methods …

SARS-CoV-2 neutralization in convalescent plasma and commercial lots of plasma-derived immunoglobulin

A Volk, C Covini-Souris, D Kuehnel, C De Mey… - BioDrugs, 2022 - Springer
Introduction Patients with primary or secondary immunodeficiency (PID or SID) face
increased insecurity and discomfort in the light of the COVID-19 pandemic, not knowing if …