Owing to the dysregulation of protein kinase activity in many diseases including cancer, this
enzyme family has become one of the most important drug targets in the 21 st century. There …

Abstract Immune-checkpoint inhibitors (ICBs), in addition to targeting CTLA-4, PD-1, and PD-
L1, novel targeting LAG-3 drugs have also been approved in clinical application. With the …

Owing to the dysregulation of protein kinase activity in many diseases including cancer, this
enzyme family has become one of the most important drug targets in the 21 st century. There …

The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …

Ru (II) polypyridyl complexes have gained widespread attention as photosensitizers for
photodynamic therapy (PDT). Herein, we systematically investigate a series of the type [Ru …

Elemene (ELE) is a group of broad-spectrum anticancer active ingredients with low toxicity
extracted from traditional Chinese medicines (TCMs), such as Curcumae Rhizoma and …

Solid tumors are complex entities that actively shape their microenvironment to create a
supportive environment for their own growth. Angiogenesis and immune suppression are …

Head and neck squamous cell carcinoma (HNSCC) is the sixth leading malignancy
worldwide, with a poor prognosis and limited treatment options. Molecularly targeted …

Purpose: Non-invasive monitoring of circulating tumor DNA (ctDNA) has the potential to be a
readily available measure for early prediction of clinical response. Here, we report on early …

Cancer remains a major cause of cancer-related death worldwide. Over 70% of epithelial
malignancies are sporadic and are related to lifestyle. Epidemiological studies suggest an …