Organ-on-chip models for infectious disease research

R Alonso-Roman, AS Mosig, MT Figge… - Nature …, 2024 - nature.com
Research on microbial pathogens has traditionally relied on animal and cell culture models
to mimic infection processes in the host. Over recent years, developments in microfluidics …

New treatment options for critically important WHO fungal priority pathogens

L Kriegl, M Egger, J Boyer, M Hoenigl… - Clinical Microbiology and …, 2024 - Elsevier
Background Yet often overlooked in public health discourse, fungal infections pose a
crucialglobal disease burden associated with annual mortality rates approximately equal to …

Inbred SJL mice recapitulate human resistance to Cryptococcus infection due to differential immune activation

MJ Davis, RE Martin, GM Pinheiro, ES Hoke, S Moyer… - Mbio, 2023 - Am Soc Microbiol
Cryptococcosis remains a significant threat to human health. While the popular C57BL/6J
mouse model of cryptococcosis has some advantages, there are some serious shortcomings …

[HTML][HTML] Connecting Cryptococcal Meningitis and Gut Microbiome

Y Ma, L Yang, M Jiang, X Zhao, P Xue - International Journal of Molecular …, 2023 - mdpi.com
Fungal pathogens of the Cryptococcus neoformans species complex (C. neoformans SC)
are a major cause of fungal meningitis in immunocompromised individuals. As with other …

[HTML][HTML] Impact factors of Blastocystis hominis infection in persons living with human immunodeficiency virus: a large-scale, multi-center observational study from …

SX Zhang, JC Wang, ZW Li, JX Zheng, WT Zhou… - Infectious Diseases of …, 2023 - Springer
Abstract Background Blastocystis hominis (Bh) is zoonotic parasitic pathogen with a high
prevalent globally, causing opportunistic infections and diarrhea disease. Human …

Vaccine development for pathogenic fungi: current status and future directions

JL Chechi, FAC da Costa, JM Figueiredo… - Expert Review of …, 2023 - Taylor & Francis
Introduction Fungal infections are caused by a broad range of pathogenic fungi that are
found worldwide with different geographic distributions, incidences, and mortality rates …

[HTML][HTML] Fungicide-tolerant persister formation during cryptococcal pulmonary infection

W Ke, Y Xie, Y Chen, H Ding, L Ye, H Qiu, H Li… - Cell Host & Microbe, 2024 - cell.com
Bacterial persisters, a subpopulation of genetically susceptible cells that are normally
dormant and tolerant to bactericides, have been studied extensively because of their clinical …

Aspartyl peptidase May1 induces host inflammatory response by altering cell wall composition in the fungal pathogen Cryptococcus neoformans

Y Li, B Chadwick, T Pham, X Xie, X Lin - Mbio, 2024 - Am Soc Microbiol
Cryptococcus neoformans causes cryptococcal meningoencephalitis, a disease that kills
more than 180,000 people annually. Contributing to its success as a fungal pathogen is its …

Illuminating the Cryptococcus neoformans Species Complex: Unveiling Intracellular Structures with Fluorescent-Protein-Based Markers

R Shi, X Lin - Genetics, 2024 - academic.oup.com
Cryptococcus neoformans is a fungal pathogen of the top critical priority recognized by the
World Health Organization. This clinically important fungus also serves as a eukaryotic …

[HTML][HTML] Emerging trends of invasive yeast infections and azole resistance in Beijing intensive care units

J Yu, W Yang, X Fan, E Cui, R Min, H Yuan… - Journal of Hospital …, 2024 - Elsevier
Invasive fungal infections pose a substantial threat to patients in healthcare settings globally.
Recent changes in the prevalence of fungal species and challenges in conducting reference …