Mitochondrial dysfunction-targeting therapeutics of natural products in Parkinson's disease

T He, X Lin, A Su, Y Zhang, Z Xing, L Mi… - Frontiers in …, 2023 - frontiersin.org
Parkinson's disease (PD), the second most common neurodegenerative disease worldwide,
often occurs in middle-aged and elderly individuals. The pathogenesis of PD is complex and …

[HTML][HTML] Role of plant derived alkaloids as antioxidant agents for neurodegenerative diseases

S Sirin, SN Dolanbay, B Aslim - Health Sciences Review, 2023 - Elsevier
Neurodegenerative diseases (NDs) encompass a broad range of conditions characterized
by progressive neuronal degeneration and death and manifesting with a variety of signs and …

Dihydromyricetin protects HUVECs of oxidative damage induced by sodium nitroprusside through activating PI3K/Akt/FoxO3a signalling pathway

X Zhang, L Wang, L Peng, X Tian, X Qiu… - Journal of Cellular …, 2019 - Wiley Online Library
The damage of vascular endothelial cells induced by oxidative stress plays an important role
in the pathogenesis of atherosclerosis. Dihydromyricetin (DMY) is considered as a natural …

[HTML][HTML] Multiple pathways for natural product treatment of Parkinson's disease: A mini review

J Li, X Long, J Hu, J Bi, T Zhou, X Guo, C Han, J Huang… - Phytomedicine, 2019 - Elsevier
Background It is established that natural medicines for Parkinson's disease (PD) provide an
antioxidant activity in preventing dopaminergic neurons from degeneration. However, the …

Nanosystems of plant-based pigments and its relationship with oxidative stress

JA Aguirre-Joya, LE Chacón-Garza… - Food and Chemical …, 2020 - Elsevier
Plant-based pigments are widely present in nature, they are classified depending on their
chemical structure as tetrapyrroles, carotenoids, polyphenolic compounds, and alkaloids …

Differential effects of silibinin a on mitochondrial function in neuronal PC12 and HepG2 liver cells

C Esselun, B Bruns, S Hagl, R Grewal… - … medicine and cellular …, 2019 - Wiley Online Library
The Mediterranean plant Silybum marianum L., commonly known as milk thistle, has been
used for centuries to treat liver disorders. The flavonolignan silibinin represents a natural …

Huperzine A and Huperzine B Production by Prothallus Cultures of Huperzia selago (L.) Bernh. ex Schrank et Mart

WJ Szypuła, B Wileńska, A Misicka, A Pietrosiuk - Molecules, 2020 - mdpi.com
This is the first report of an efficient and effective procedure to optimize the biosynthesis of
huperzine A (HupA) and huperzine B (HupB) in vitro from Huperzia selago gametophytes …

The use of Huperzia species for the treatment of Alzheimer's disease

D Kim Thu, DT Vui, NT Ngoc Huyen… - Journal of Basic and …, 2020 - degruyter.com
Abstract Alzheimer's disease (AD), which relates to nervous degeneration, is the most
popular form of memory loss. The pathogenesis of AD is not fully understood, and there are …

Biology, phytochemistry, pharmacology, and biotechnology of European ferns, Club mosses, and horsetails: a review

WJ Szypuła, A Pietrosiuk - Medicinal Plants: Domestication, Biotechnology …, 2021 - Springer
Pteridophytes found in Europe have been used for centuries for a variety of ailments but
compared to angiosperms they constitute a relatively small group of medicinal plants. The …

Impact of Silibinin A on Bioenergetics in PC12APPsw Cells and Mitochondrial Membrane Properties in Murine Brain Mitochondria

C Esselun, B Bruns, S Hagl, R Grewal, GP Eckert - Antioxidants, 2021 - mdpi.com
Age-related multifactorial diseases, such as the neurodegenerative Alzheimer's disease
(AD), still remain a challenge to today's society. One mechanism associated with AD and …