Most life scientists would agree that understanding how cellular processes work requires
structural knowledge about the macromolecules involved. For example, deciphering the …

Biology spans a continuum of length and time scales. Individual experimental methods only
glimpse discrete pieces of this spectrum but can be combined to construct a more holistic …

In situ cryo-electron tomography enables investigation of macromolecules in their native
cellular environment. Samples have become more readily available owing to recent …

The extracellular matrix (ECM) serves as a scaffold for cells and plays an essential role in
regulating numerous cellular processes, including cell migration and proliferation. Due to …

Cryo-focused ion beam milling has substantially advanced our understanding of molecular
processes by opening windows into cells. However, applying this technique to complex …

We envision'AI scientists' as systems capable of skeptical learning and reasoning that
empower biomedical research through collaborative agents that integrate machine learning …

Cryo-electron tomography allows the routine visualization of cellular landscapes in three
dimensions at nanometer-range resolutions. When combined with single-particle …

Imaging technologies have played a pivotal role in advancing biological research by
enabling visualization of biological structures and processes. While traditional electron …

Cryo-electron tomography (cryo-ET) allows high resolution 3D imaging of biological
samples in near-native environments. Thus, cryo-ET has become the method of choice to …

Cryogenic-focused ion beam (cryo-FIB) instruments became essential for high-resolution
imaging in cryo-preserved cells and tissues. Cryo-FIBs use accelerated ions to thin samples …