Effects of air pollution on human health–mechanistic evidence suggested by in vitro and in vivo modelling

H Chen, BG Oliver, A Pant, A Olivera, P Poronnik… - Environmental …, 2022 - Elsevier
Airborne particulate matter (PM) comprises both solid and liquid particles, including carbon,
sulphates, nitrate, and toxic heavy metals, which can induce oxidative stress and …

Lipid composition of cell membranes and its relevance in type 2 diabetes mellitus

R NM Weijers - Current diabetes reviews, 2012 - ingentaconnect.com
Identifying the causative relationship between the fatty acid composition of cell membranes
and type 2 diabetes mellitus fundamentally contributes to the understanding of the basic …

Elevating CXCR7 improves angiogenic function of EPCs via Akt/GSK-3β/Fyn-mediated Nrf2 activation in diabetic limb ischemia

X Dai, X Yan, J Zeng, J Chen, Y Wang, J Chen… - Circulation …, 2017 - Am Heart Assoc
Rationale: Endothelial progenitor cells (EPCs) respond to stromal cell–derived factor 1 (SDF-
1) through chemokine receptors CXCR7 and CXCR4. Whether SDF-1 receptors involves in …

Neuroprotective panel of olive polyphenols: Mechanisms of action, anti-demyelination, and anti-stroke properties

T Grubić Kezele, B Ćurko-Cofek - Nutrients, 2022 - mdpi.com
Neurological diseases such as stroke and multiple sclerosis are associated with high
morbidity and mortality, long-term disability, and social and economic burden. Therefore …

Topical reappraisal of molecular pharmacological approaches to endothelial dysfunction in diabetes mellitus angiopathy

C Munteanu, M Rotariu, MA Turnea… - Current Issues in …, 2022 - mdpi.com
Diabetes mellitus (DM) is a frequent medical problem, affecting more than 4% of the
population in most countries. In the context of diabetes, the vascular endothelium can play a …

FGF 21 deletion exacerbates diabetic cardiomyopathy by aggravating cardiac lipid accumulation

X Yan, J Chen, C Zhang, S Zhou… - Journal of cellular …, 2015 - Wiley Online Library
Abstract Fibroblast growth factor 21 (FGF 21) plays an important role in energy
homoeostasis. The unaddressed question of FGF 21's effect on the development and …

[HTML][HTML] Additive manufacturing of degradable metallic scaffolds for material-structure-driven diabetic maxillofacial bone regeneration

W Song, D Zhao, F Guo, J Wang, Y Wang, X Wang… - Bioactive Materials, 2024 - Elsevier
The regeneration of maxillofacial bone defects associated with diabetes mellitus remains
challenging due to the occlusal loading and hyperglycemia microenvironment. Herein, we …

Neovascularization and tissue regeneration by endothelial progenitor cells in ischemic stroke

J Li, Y Ma, XH Miao, JD Guo, DW Li - Neurological sciences, 2021 - Springer
Endothelial progenitor cells (EPCs) are immature endothelial cells (ECs) capable of
proliferating and differentiating into mature ECs. These progenitor cells migrate from bone …

Sitagliptin‐mediated preservation of endothelial progenitor cell function via augmenting autophagy enhances ischaemic angiogenesis in diabetes

X Dai, J Zeng, X Yan, Q Lin, K Wang… - Journal of Cellular …, 2018 - Wiley Online Library
Abstract Recently, the dipeptidyl peptidase‐4 (DPP‐4) inhibitor sitagliptin, a major anti‐
hyperglycaemic agent, has received substantial attention as a therapeutic target for …

Nrf2 protects against diabetic dysfunction of endothelial progenitor cells via regulating cell senescence

RY Wang, LH Liu, H Liu, KF Wu… - International …, 2018 - spandidos-publications.com
Diabetes is associated with an increased risk of cardiovascular disease. A decrease in the
number and functionality of endothelial progenitor cells (EPCs) leads to reduced endothelial …