Self-healing injectable hydrogels for tissue regeneration

P Bertsch, M Diba, DJ Mooney… - Chemical …, 2022 - ACS Publications
Biomaterials with the ability to self-heal and recover their structural integrity offer many
advantages for applications in biomedicine. The past decade has witnessed the rapid …

Self-assembling peptide EAK16 and RADA16 nanofiber scaffold hydrogel

F Gelain, Z Luo, S Zhang - Chemical reviews, 2020 - ACS Publications
Short peptides are ubiquitous in nature. They are found as hormones, pheromones,
antibacterial and antifungal agents in innate immunity systems, toxins, and pesticides. But …

[HTML][HTML] Injectable hydrogels in central nervous system: Unique and novel platforms for promoting extracellular matrix remodeling and tissue engineering

E Hasanzadeh, A Seifalian, A Mellati, J Saremi… - Materials Today Bio, 2023 - Elsevier
Repairing central nervous system (CNS) is difficult due to the inability of neurons to recover
after damage. A clinically acceptable treatment to promote CNS functional recovery and …

[HTML][HTML] Self-assemble peptide biomaterials and their biomedical applications

J Chen, X Zou - Bioactive materials, 2019 - Elsevier
Inspired by self-assembling peptides found in native proteins, deliberately designed
engineered peptides have shown outstanding biocompatibility, biodegradability, and …

An injectable hydrogel enhances tissue repair after spinal cord injury by promoting extracellular matrix remodeling

LTA Hong, YM Kim, HH Park, DH Hwang, Y Cui… - Nature …, 2017 - nature.com
The cystic cavity that develops following injuries to brain or spinal cord is a major obstacle
for tissue repair in central nervous system (CNS). Here we report that injection of imidazole …

Hydrogel systems and their role in neural tissue engineering

P Madhusudanan, G Raju… - Journal of the Royal …, 2020 - royalsocietypublishing.org
Neural tissue engineering (NTE) is a rapidly progressing field that promises to address
several serious neurological conditions that are currently difficult to treat. Selecting the right …

Self-assembling peptide scaffolds in the clinic

F Gelain, Z Luo, M Rioult, S Zhang - NPJ Regenerative medicine, 2021 - nature.com
Well-defined scaffold hydrogels made of self-assembling peptides have found their way into
clinical products. By examining the properties and applications of two self-assembling …

The effect of a nanofiber-hydrogel composite on neural tissue repair and regeneration in the contused spinal cord

X Li, C Zhang, AE Haggerty, J Yan, M Lan, M Seu… - Biomaterials, 2020 - Elsevier
An injury to the spinal cord causes long-lasting loss of nervous tissue because endogenous
nervous tissue repair and regeneration at the site of injury is limited. We engineered an …

Three-dimensional aligned nanofibers-hydrogel scaffold for controlled non-viral drug/gene delivery to direct axon regeneration in spinal cord injury treatment

LH Nguyen, M Gao, J Lin, W Wu, J Wang, SY Chew - Scientific reports, 2017 - nature.com
Spinal cord injuries (SCI) often lead to persistent neurological dysfunction due to failure in
axon regeneration. Unfortunately, currently established treatments, such as direct drug …

Injectable hydrogel materials for spinal cord regeneration: a review

D Macaya, M Spector - Biomedical materials, 2012 - iopscience.iop.org
Spinal cord injury (SCI) presents a complex regenerative problem due to the multiple facets
of growth inhibition that occur following trauma to the cord parenchyma and stroma …