Clustered regularly interspaced short palindromic repeat (CRISPR) and their associated
protein (Cas-9) is the most effective, efficient, and accurate method of genome editing tool in …

Cellular senescence is a state of irreversible cell cycle arrest associated with ageing.
Senescence of different cardiac cell types can direct the pathophysiology of cardiovascular …

Macrophages are essential for skeletal muscle homeostasis, but how their dysregulation
contributes to the development of fibrosis in muscle disease remains unclear. Here, we used …

Background Cachexia, a multifactorial syndrome affecting more than 50% of patients with
advanced cancer and responsible for~ 20% of cancer‐associated deaths, is still a poorly …

Importance It is currently unknown how often and in which ways a genetic diagnosis given to
a patient with epilepsy is associated with clinical management and outcomes. Objective To …

Duchenne muscular dystrophy is a highly progressive muscle wasting disorder due to
primary abnormalities in one of the largest genes in the human genome, the DMD gene …

Targeted protein degradation by proteolysis-targeting chimera (PROTAC) is one of the
exciting modalities for drug discovery and biological discovery. It is important to select an …

Duchenne muscular dystrophy (DMD) is a neuromuscular disorder brought on by mutations
in the DMD gene, which prevent muscle cells from expressing the dystrophin protein …

Downregulation of genes involved in the secondary pathology of Duchenne muscular
dystrophy, for example, inflammation, fibrosis, and adiposis, is an interesting approach to …

High systemic doses of adeno-associated viruses (AAVs) have been associated with
immune-related serious adverse events (SAEs). Although AAV was well tolerated in …