Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Type 1 diabetes mellitus (T1DM) is the most common chronic autoimmune disease in young
patients and is characterized by the loss of pancreatic β cells; as a result, the body becomes …

Aging increases the susceptibility to a diverse set of diseases and disorders, including
neurodegeneration, cancer, diabetes, and arthritis. Natural compounds are currently being …

Abstract Background Type 2 diabetes (T2D) is a common metabolic disease. Variants in
human IGF2 mRNA binding protein 2 (IMP2/IGF2BP2) are associated with increased risk of …

The current drugs for the treatment of type 2 diabetes mellitus (T2DM) can cause side effects
after long-time use. Hence, the novel drugs were urgent need to developed for T2DM …

Vertebrate embryonic development requires specific signaling events that regulate cell
proliferation and differentiation to occur at the correct place and the correct time in order to …

The glucagon-like peptide 1 (Glp-1) has emerged as a hormone with broad pharmacological
potential in type 2 diabetes (T2D) treatment, notably by improving β cell functions. The cell …

Increasingly, epidemiological evidences indicate chemosynthetic perfluorooctanoic acid
(PFOA), an environmental pollutant, induces potential adverse effect on human health after …

The Hippo signaling pathway is a vital regulator of pancreatic development and
homeostasis, directing cell fate decisions, morphogenesis, and adult pancreatic cellular …

Pancreatic beta cells sense changes in nutrients during the cycles of fasting and feeding
and release insulin accordingly to maintain glucose homeostasis. Abnormal beta cell …