Mitotic spindle orientation is essential for cell fate decisions, epithelial maintenance, and
tissue morphogenesis. In most animal cell types, the dynein motor complex is anchored at …

The cytoskeleton—comprising actin filaments, microtubules and intermediate filaments—
serves instructive roles in regulating cell function and behaviour during development …

The position and orientation of the mitotic spindle is precisely regulated to ensure the
accurate partition of the cytoplasm between daughter cells and the correct localization of the …

Both cell–cell adhesion and oriented cell division play prominent roles in establishing tissue
architecture, but it is unclear how they might be coordinated. Here, we demonstrate that the …

During epithelial cell proliferation, planar alignment of the mitotic spindle coordinates the
local process of symmetric cell cleavage with the global maintenance of polarized tissue …

In both plants and animals, multiple cellular processes must be orchestrated to ensure
proper organogenesis. The cell division patterns control the shape of growing organs, yet …

Cell polarity is fundamental for the architecture and function of epithelial tissues. Epithelial
polarization requires the intervention of several fundamental cell processes, whose …

CEP63 is a centrosomal protein that facilitates centriole duplication and is regulated by the
DNA damage response. Mutations in CEP63 cause Seckel syndrome, a human disease …

Epithelia are polarized layers of adherent cells that are the building blocks for organ and
appendage structures throughout animals. To preserve tissue architecture and barrier …

Tissue morphogenesis requires the coordinated regulation of cellular behavior, which
includes the orientation of cell division that defines the position of daughter cells in the …