COVID-19 is characterized by excessive production of pro-inflammatory cytokines and acute
lung damage associated with patient mortality. While multiple inflammatory cytokines are …

Danger signals are a hallmark of many common inflammatory diseases, and these stimuli
can function to activate the cytosolic innate immune signalling receptor NLRP3 (NOD-, LRR …

Caspases are an evolutionary conserved family of cysteine proteases that are centrally
involved in cell death and inflammation responses. A wealth of foundational insight into the …

The inflammasome is a cytosolic immune signaling complex that induces inflammation and
pyroptosis. Inflammasome complexes respond to a variety of pathogens, as well as danger …

Various forms of cell death have been identified over the last decades with each relying on a
different subset of proteins for the activation and execution of their respective pathway (s). In …

Mortality among patients with chronic kidney disease (CKD) is largely a consequence of
cardiovascular disease (CVD) and is a particular concern given the increasing prevalence of …

Alzheimer's disease (AD) is a neurodegenerative disorder molecularly characterized by the
formation of amyloid β (Aβ) plaques and type 2 microtubule-associated protein (Tau) …

The pro-inflammatory immune response driven by microglia is a key contributor to the
pathogenesis of several neurodegenerative diseases. Though the research of microglia …

NLRP3 inflammasome can be widely found in epithelial cells and immune cells. The NOD-
like receptors (NLRs) family member NLRP3 contains a central nucleotide-binding and …

The immune system plays a critical role in shaping all facets of cancer, from the early
initiation stage through to metastatic disease and resistance to therapy. Our understanding …