Origins of HIV and the AIDS pandemic

PM Sharp, BH Hahn - Cold Spring …, 2011 - perspectivesinmedicine.cshlp.org
Acquired immunodeficiency syndrome (AIDS) of humans is caused by two lentiviruses,
human immunodeficiency viruses types 1 and 2 (HIV-1 and HIV-2). Here, we describe the …

HIV pathogenesis: 25 years of progress and persistent challenges

JA Levy - Aids, 2009 - journals.lww.com
In 1981, a new disease syndrome appeared in human populations in the United States and
elsewhere characterized by a deficiency in the immune system [1]. Patients presented with …

Simian Immunodeficiency Virus Infection in Free-Ranging Sooty Mangabeys (Cercocebus atys atys) from the Taï Forest, Côte d'Ivoire: Implications for the Origin of …

ML Santiago, F Range, BF Keele, Y Li, E Bailes… - Journal of …, 2005 - Am Soc Microbiol
Simian immunodeficiency virus of sooty mangabeys (SIVsmm) is recognized as the
progenitor of human immunodeficiency virus type 2 (HIV-2) and has been transmitted to …

[PDF][PDF] Update on HIV-1 diversity in Africa: a decade in review

RW Lihana, D Ssemwanga, A Abimiku, N Ndembi - Aids Rev, 2012 - researchgate.net
Background: HIV-1 strains have diversified extensively through mutation and recombination
since their initial transmission to human beings many decades ago in Central Africa in the …

Geographic distribution, virologic and clinical characteristics of hepatitis B virus genotypes in China

G Zeng, Z Wang, S Wen, J Jiang, L Wang… - Journal of viral …, 2005 - Wiley Online Library
The significance of hepatitis B virus (HBV) genotypes for the heterogeneity of chronic HBV
infection and severity of liver disease is not well understood. The aim of this study was to …

GenGIS: A geospatial information system for genomic data

DH Parks, M Porter, S Churcher, S Wang… - Genome …, 2009 - genome.cshlp.org
The increasing availability of genetic sequence data associated with explicit geographic and
ecological information is offering new opportunities to study the processes that shape …

The role of recombination in the emergence of a complex and dynamic HIV epidemic

M Zhang, B Foley, AK Schultz, JP Macke, I Bulla… - Retrovirology, 2010 - Springer
Background Inter-subtype recombinants dominate the HIV epidemics in three geographical
regions. To better understand the role of HIV recombinants in shaping the current HIV …

Impact of HIV-1 genetic diversity on plasma HIV-1 RNA Quantification: usefulness of the Agence Nationale de Recherches sur le SIDA second-generation long …

F Rouet, ML Chaix, E Nerrienet… - JAIDS Journal of …, 2007 - journals.lww.com
The high genetic diversity of HIV-1 has a major impact on the quantification of plasma HIV-1
RNA, representing an increasingly difficult challenge. A total of 898 plasma specimens …

Appreciating HIV type 1 diversity: subtype differences in Env

RM Lynch, T Shen, S Gnanakaran… - AIDS research and …, 2009 - liebertpub.com
Human immunodeficiency virus type 1 (HIV-1) group M is responsible for the current AIDS
pandemic and exhibits exceedingly high levels of viral genetic diversity around the world …

Modern-day SIV viral diversity generated by extensive recombination and cross-species transmission

SM Bell, T Bedford - PLoS pathogens, 2017 - journals.plos.org
Cross-species transmission (CST) has led to many devastating epidemics, but is still a
poorly understood phenomenon. HIV-1 and HIV-2 (human immunodeficiency virus 1 and 2) …