[HTML][HTML] Progress and insights toward an effective placental malaria vaccine

B Gamain, A Chêne, NK Viebig… - Frontiers in …, 2021 - frontiersin.org
In areas where Plasmodium falciparum transmission is endemic, clinical immunity against
malaria is progressively acquired during childhood and adults are usually protected against …

VAR2CSA and protective immunity against pregnancy-associated Plasmodium falciparum malaria

L Hviid, A Salanti - Parasitology, 2007 - cambridge.org
People living in areas with stable transmission of P. falciparum parasites acquire protective
immunity to malaria over a number of years and following multiple disease episodes …

Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA

A Srivastava, S Gangnard, A Round… - Proceedings of the …, 2010 - National Acad Sciences
Pregnancy-associated malaria (PAM) is a serious consequence of sequestration of
Plasmodium falciparum-parasitized erythrocytes (PE) in the placenta through adhesion to …

[HTML][HTML] Full-length recombinant Plasmodium falciparum VAR2CSA binds specifically to CSPG and induces potent parasite adhesion-blocking antibodies

P Khunrae, M Dahlbäck, MA Nielsen… - Journal of molecular …, 2010 - Elsevier
Plasmodium falciparum malaria remains one of the world's leading causes of human
suffering and poverty. Each year, the disease takes 1–3 million lives, mainly in sub-Saharan …

Human pregnancy‐associated malaria‐specific B cells target polymorphic, conformational epitopes in VAR2CSA: This article became available OnlineOpen after it …

L Barfod, NL Bernasconi, M Dahlbäck… - Molecular …, 2007 - Wiley Online Library
Pregnancy‐associated malaria (PAM) is caused by Plasmodium falciparum‐infected
erythrocytes (IEs) that bind to chondroitin sulphate A (CSA) in the placenta by PAM …

[HTML][HTML] Var2CSA minimal CSA binding region is located within the N-terminal region

A Srivastava, S Gangnard, S Dechavanne, F Amirat… - PloS one, 2011 - journals.plos.org
Var2CSA, a key molecule linked with pregnancy-associated malaria (PAM), causes
sequestration of Plasmodium falciparum infected erythrocytes (PEs) in the placenta by …

Analysis of Plasmodium falciparum var Genes Expressed in Children from Papua New Guinea

N Falk, M Kaestli, W Qi, M Ott, K Baea… - Journal of infectious …, 2009 - academic.oup.com
Background The variable antigen P. falciparum erythrocyte membrane protein-1 (PfEMP1) is
a major virulence factor in malaria. A large number of var genes encode PfEMP1, and we …

An In Vivo and In Vitro Model of Plasmodium falciparum Rosetting and Autoagglutination Mediated by varO, a Group A var Gene Encoding a Frequent Serotype

I Vigan-Womas, M Guillotte, C Le Scanf… - Infection and …, 2008 - Am Soc Microbiol
In the Saimiri sciureus monkey, erythrocytes infected with the varO antigenic variant of the
Plasmodium falciparum Palo Alto 89F5 clone bind uninfected red blood cells (rosetting) …

[HTML][HTML] The molecular mechanism of cytoadherence to placental or tumor cells through VAR2CSA from Plasmodium falciparum

W Wang, Z Wang, X Yang, Y Gao, X Zhang, L Cao… - Cell discovery, 2021 - nature.com
Dear Editor, Pregnancy-associated malaria (PAM) threatened more than one million women
and their infants in endemic regions in 2019. This resulted in maternal anemia, stillbirth, and …

Pre-clinical and clinical development of the first placental malaria vaccine

C Pehrson, A Salanti, TG Theander… - Expert Review of …, 2017 - Taylor & Francis
Introduction: Malaria during pregnancy is a massive health problem in endemic areas.
Placental malaria infections caused by Plasmodium falciparum are responsible for up to one …