A 360 view of the inflammasome: Mechanisms of activation, cell death, and diseases

KC Barnett, S Li, K Liang, JPY Ting - Cell, 2023 - cell.com
Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …

Interplay between NLRP3 inflammasome and autophagy

M Biasizzo, N Kopitar-Jerala - Frontiers in Immunology, 2020 - frontiersin.org
The NLRP3 inflammasome is cytosolic multi-protein complex that induces inflammation and
pyroptotic cell death in response to both pathogen (PAMPs) and endogenous activators …

IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting

L Broderick, HM Hoffman - Nature Reviews Rheumatology, 2022 - nature.com
Over 20 years ago, it was first proposed that autoinflammation underpins a handful of rare
monogenic disorders characterized by recurrent fever and systemic inflammation. The …

Emerging activators and regulators of inflammasomes and pyroptosis

Y Xue, DE Tuipulotu, WH Tan, C Kay, SM Man - Trends in immunology, 2019 - cell.com
The inflammasome is a cytosolic immune signaling complex that induces inflammation and
pyroptosis. Inflammasome complexes respond to a variety of pathogens, as well as danger …

Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome

X Shi, Q Sun, Y Hou, H Zeng, Y Cao, M Dong, J Ding… - Nature, 2023 - nature.com
Abstract The canonical (caspase-1) and noncanonical (comprising caspases 4, 5 and 11;
hereafter, caspase-4/5/11) inflammasomes both cleave gasdermin D (GSDMD) to induce …

The pyrin inflammasome in health and disease

O Schnappauf, JJ Chae, DL Kastner… - Frontiers in …, 2019 - frontiersin.org
The pyrin inflammasome has evolved as an innate immune sensor to detect bacterial toxin-
induced Rho guanosine triphosphatase (Rho GTPase)-inactivation, a process that is similar …

Inflammasomes: mechanism of assembly, regulation and signalling

P Broz, VM Dixit - Nature Reviews Immunology, 2016 - nature.com
Inflammasomes are multiprotein signalling platforms that control the inflammatory response
and coordinate antimicrobial host defences. They are assembled by pattern-recognition …

Classification criteria for autoinflammatory recurrent fevers

M Gattorno, M Hofer, S Federici, F Vanoni… - Annals of the …, 2019 - ard.bmj.com
Background Different diagnostic and classification criteria are available for hereditary
recurrent fevers (HRF)—familial Mediterranean fever (FMF), tumour necrosis factor receptor …

The NLRP3 inflammasome: contributions to inflammation-related diseases

Y Chen, X Ye, G Escames, W Lei, X Zhang, M Li… - Cellular & molecular …, 2023 - Springer
The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates
innate immune responses by activating caspase-1 and the inflammatory cytokines …

Inflammasome activation and assembly at a glance

A Malik, TD Kanneganti - Journal of cell science, 2017 - journals.biologists.com
Inflammasomes are multimeric protein complexes that typically comprise a sensor, an
adaptor and the zymogen procaspase-1. An inflammasome assembles in response to a …