A 360 view of the inflammasome: Mechanisms of activation, cell death, and diseases
Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …
the host through recognition of distinct molecules, known as pathogen-or damage …
Interplay between NLRP3 inflammasome and autophagy
M Biasizzo, N Kopitar-Jerala - Frontiers in Immunology, 2020 - frontiersin.org
The NLRP3 inflammasome is cytosolic multi-protein complex that induces inflammation and
pyroptotic cell death in response to both pathogen (PAMPs) and endogenous activators …
pyroptotic cell death in response to both pathogen (PAMPs) and endogenous activators …
IL-1 and autoinflammatory disease: biology, pathogenesis and therapeutic targeting
L Broderick, HM Hoffman - Nature Reviews Rheumatology, 2022 - nature.com
Over 20 years ago, it was first proposed that autoinflammation underpins a handful of rare
monogenic disorders characterized by recurrent fever and systemic inflammation. The …
monogenic disorders characterized by recurrent fever and systemic inflammation. The …
Emerging activators and regulators of inflammasomes and pyroptosis
The inflammasome is a cytosolic immune signaling complex that induces inflammation and
pyroptosis. Inflammasome complexes respond to a variety of pathogens, as well as danger …
pyroptosis. Inflammasome complexes respond to a variety of pathogens, as well as danger …
Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome
Abstract The canonical (caspase-1) and noncanonical (comprising caspases 4, 5 and 11;
hereafter, caspase-4/5/11) inflammasomes both cleave gasdermin D (GSDMD) to induce …
hereafter, caspase-4/5/11) inflammasomes both cleave gasdermin D (GSDMD) to induce …
The pyrin inflammasome in health and disease
The pyrin inflammasome has evolved as an innate immune sensor to detect bacterial toxin-
induced Rho guanosine triphosphatase (Rho GTPase)-inactivation, a process that is similar …
induced Rho guanosine triphosphatase (Rho GTPase)-inactivation, a process that is similar …
Inflammasomes: mechanism of assembly, regulation and signalling
Inflammasomes are multiprotein signalling platforms that control the inflammatory response
and coordinate antimicrobial host defences. They are assembled by pattern-recognition …
and coordinate antimicrobial host defences. They are assembled by pattern-recognition …
Classification criteria for autoinflammatory recurrent fevers
M Gattorno, M Hofer, S Federici, F Vanoni… - Annals of the …, 2019 - ard.bmj.com
Background Different diagnostic and classification criteria are available for hereditary
recurrent fevers (HRF)—familial Mediterranean fever (FMF), tumour necrosis factor receptor …
recurrent fevers (HRF)—familial Mediterranean fever (FMF), tumour necrosis factor receptor …
The NLRP3 inflammasome: contributions to inflammation-related diseases
Y Chen, X Ye, G Escames, W Lei, X Zhang, M Li… - Cellular & molecular …, 2023 - Springer
The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates
innate immune responses by activating caspase-1 and the inflammatory cytokines …
innate immune responses by activating caspase-1 and the inflammatory cytokines …
Inflammasome activation and assembly at a glance
A Malik, TD Kanneganti - Journal of cell science, 2017 - journals.biologists.com
Inflammasomes are multimeric protein complexes that typically comprise a sensor, an
adaptor and the zymogen procaspase-1. An inflammasome assembles in response to a …
adaptor and the zymogen procaspase-1. An inflammasome assembles in response to a …