Peptide therapeutics are acclaimed as a promising addition to the pharmaceutical arena,
and they continue to attract interest due to their high potency, bioavailability, and fewer …

The use of polymer-supported reagents and scavengers provides an attractive and practical
method for the clean and efficient preparation of novel chemical libraries with potential …

The review addresses the functional and structural properties of the two series of chalcogen
analogues of amino acids in peptides and proteins, the methionine and the serine/cysteine …

About one fourth of the peptidic macromolecular structures deposited in the protein data
base (PDB) contain at least one disulfide bridge.[1] In nature, disulfide bonds are formed in a …

Immunogenic responses by protein therapeutics often lead to reduced therapeutic effects
and/or adverse effects via the generation of neutralizing antibodies and/or antidrug …

There are approximately 500 species of predatory cone snails within the genus Conus. They
comprise what is arguably the largest single genus of marine animals alive today. It has …

Conopeptides from> 700 species of predatory marine Conus snails provide an impressive
molecular diversity of cysteine-rich peptides. Most of the estimated 50,000–100,000 distinct …

The complex mixture of biologically active peptides that constitute the venom of Conus
species provides a rich source of ion channel neurotoxins. These peptides, commonly …

The disulfide bond plays an important role in biological systems. It defines global
conformation, and ultimately the biological activity and stability of the peptide or protein. It is …

Identifying the Cys residues involved in disulfide linkages of peptides and proteins that
contain complex disulfide bond patterns is a significant analytical challenge. This is …