[HTML][HTML] The flexibility of Apicomplexa parasites in lipid metabolism
Apicomplexa are obligate intracellular parasites responsible for major human infectious
diseases such as toxoplasmosis and malaria, which pose social and economic burdens …
diseases such as toxoplasmosis and malaria, which pose social and economic burdens …
[HTML][HTML] Toxoplasma metabolic flexibility in different growth conditions
Apicomplexan parasites have complex metabolic networks that coordinate acquisition of
metabolites by de novo synthesis and by scavenging from the host. Toxoplasma gondii has …
metabolites by de novo synthesis and by scavenging from the host. Toxoplasma gondii has …
[PDF][PDF] A Plasmodium falciparum lysophospholipase regulates host fatty acid flux via parasite lipid storage to enable controlled asexual schizogony
Phospholipid metabolism is crucial for membrane biogenesis and homeostasis of
Plasmodium falciparum. To generate such phospholipids, the parasite extensively …
Plasmodium falciparum. To generate such phospholipids, the parasite extensively …
[HTML][HTML] A positive feedback loop mediates crosstalk between calcium, cyclic nucleotide and lipid signalling in calcium-induced Toxoplasma gondii egress
Fundamental processes that govern the lytic cycle of the intracellular parasite Toxoplasma
gondii are regulated by several signalling pathways. However, how these pathways are …
gondii are regulated by several signalling pathways. However, how these pathways are …
[HTML][HTML] Disrupting the plastidic iron-sulfur cluster biogenesis pathway in Toxoplasma gondii has pleiotropic effects irreversibly impacting parasite viability
EA Renaud, S Pamukcu, A Cerutti, L Berry… - Journal of Biological …, 2022 - ASBMB
Like many other apicomplexan parasites, Toxoplasma gondii contains a plastid harboring
key metabolic pathways, including the sulfur utilization factor (SUF) pathway that is involved …
key metabolic pathways, including the sulfur utilization factor (SUF) pathway that is involved …
[HTML][HTML] Synthesis vs. salvage of ester- and ether-linked phosphatidylethanolamine in the intracellular protozoan pathogen Toxoplasma gondii
B Ren, X Liang, JF Brouwers, RC Miron… - Communications …, 2023 - nature.com
Toxoplasma gondii is a prevalent zoonotic pathogen infecting livestock as well as humans.
The exceptional ability of this parasite to reproduce in several types of nucleated host cells …
The exceptional ability of this parasite to reproduce in several types of nucleated host cells …
[HTML][HTML] The patatin-like phospholipase PfPNPLA2 is involved in the mitochondrial degradation of phosphatidylglycerol during Plasmodium falciparum blood stage …
S Shunmugam, N Quansah… - Frontiers in Cellular …, 2023 - ncbi.nlm.nih.gov
Plasmodium falciparum is an Apicomplexa responsible for human malaria, a major disease
causing more than ½ million deaths every year, against which there is no fully efficient …
causing more than ½ million deaths every year, against which there is no fully efficient …
[HTML][HTML] The Toxoplasma protein phosphatase 6 catalytic subunit (TgPP6C) is essential for cell cycle progression and virulence
QL Liang, LB Nie, HM Elsheikha, TT Li, LX Sun… - PLoS …, 2023 - journals.plos.org
Protein phosphatases are post-translational regulators of Toxoplasma gondii proliferation,
tachyzoite-bradyzoite differentiation and pathogenesis. Here, we identify the putative protein …
tachyzoite-bradyzoite differentiation and pathogenesis. Here, we identify the putative protein …
The acyl-CoA synthetase TgACS1 allows neutral lipid metabolism and extracellular motility in Toxoplasma gondii through relocation via its peroxisomal targeting …
S Charital, S Shunmugam, S Dass, AM Alazzi… - Mbio, 2024 - Am Soc Microbiol
Apicomplexa parasites cause major diseases such as toxoplasmosis and malaria that have
major health and economic burdens. These unicellular pathogens are obligate intracellular …
major health and economic burdens. These unicellular pathogens are obligate intracellular …
[HTML][HTML] Fatty Acid Profiles of Leishmania major Derived from Human and Rodent Hosts in Endemic Cutaneous Leishmaniasis Areas of Tunisia and Algeria
C Bouabid, Y Yamaryo-Botté, S Rabhi, H Bichiou… - Pathogens, 2022 - mdpi.com
Leishmaniasis is a protozoal vector-borne disease that affects both humans and animals. In
the Mediterranean Basin, the primary reservoir hosts of Leishmania spp. are mainly rodents …
the Mediterranean Basin, the primary reservoir hosts of Leishmania spp. are mainly rodents …