[HTML][HTML] The flexibility of Apicomplexa parasites in lipid metabolism

S Shunmugam, CS Arnold, S Dass, NJ Katris… - PLoS …, 2022 - journals.plos.org
Apicomplexa are obligate intracellular parasites responsible for major human infectious
diseases such as toxoplasmosis and malaria, which pose social and economic burdens …

[HTML][HTML] Toxoplasma metabolic flexibility in different growth conditions

D Walsh, NJ Katris, L Sheiner, CY Botté - Trends in parasitology, 2022 - cell.com
Apicomplexan parasites have complex metabolic networks that coordinate acquisition of
metabolites by de novo synthesis and by scavenging from the host. Toxoplasma gondii has …

[PDF][PDF] A Plasmodium falciparum lysophospholipase regulates host fatty acid flux via parasite lipid storage to enable controlled asexual schizogony

PK Sheokand, Y Yamaryo-Botte, M Narwal, CS Arnold… - Cell Reports, 2023 - cell.com
Phospholipid metabolism is crucial for membrane biogenesis and homeostasis of
Plasmodium falciparum. To generate such phospholipids, the parasite extensively …

[HTML][HTML] A positive feedback loop mediates crosstalk between calcium, cyclic nucleotide and lipid signalling in calcium-induced Toxoplasma gondii egress

SD Nofal, C Dominicus, M Broncel, NJ Katris… - PLoS …, 2022 - journals.plos.org
Fundamental processes that govern the lytic cycle of the intracellular parasite Toxoplasma
gondii are regulated by several signalling pathways. However, how these pathways are …

[HTML][HTML] Disrupting the plastidic iron-sulfur cluster biogenesis pathway in Toxoplasma gondii has pleiotropic effects irreversibly impacting parasite viability

EA Renaud, S Pamukcu, A Cerutti, L Berry… - Journal of Biological …, 2022 - ASBMB
Like many other apicomplexan parasites, Toxoplasma gondii contains a plastid harboring
key metabolic pathways, including the sulfur utilization factor (SUF) pathway that is involved …

[HTML][HTML] Synthesis vs. salvage of ester- and ether-linked phosphatidylethanolamine in the intracellular protozoan pathogen Toxoplasma gondii

B Ren, X Liang, JF Brouwers, RC Miron… - Communications …, 2023 - nature.com
Toxoplasma gondii is a prevalent zoonotic pathogen infecting livestock as well as humans.
The exceptional ability of this parasite to reproduce in several types of nucleated host cells …

[HTML][HTML] The patatin-like phospholipase PfPNPLA2 is involved in the mitochondrial degradation of phosphatidylglycerol during Plasmodium falciparum blood stage …

S Shunmugam, N Quansah… - Frontiers in Cellular …, 2023 - ncbi.nlm.nih.gov
Plasmodium falciparum is an Apicomplexa responsible for human malaria, a major disease
causing more than ½ million deaths every year, against which there is no fully efficient …

[HTML][HTML] The Toxoplasma protein phosphatase 6 catalytic subunit (TgPP6C) is essential for cell cycle progression and virulence

QL Liang, LB Nie, HM Elsheikha, TT Li, LX Sun… - PLoS …, 2023 - journals.plos.org
Protein phosphatases are post-translational regulators of Toxoplasma gondii proliferation,
tachyzoite-bradyzoite differentiation and pathogenesis. Here, we identify the putative protein …

The acyl-CoA synthetase TgACS1 allows neutral lipid metabolism and extracellular motility in Toxoplasma gondii through relocation via its peroxisomal targeting …

S Charital, S Shunmugam, S Dass, AM Alazzi… - Mbio, 2024 - Am Soc Microbiol
Apicomplexa parasites cause major diseases such as toxoplasmosis and malaria that have
major health and economic burdens. These unicellular pathogens are obligate intracellular …

[HTML][HTML] Fatty Acid Profiles of Leishmania major Derived from Human and Rodent Hosts in Endemic Cutaneous Leishmaniasis Areas of Tunisia and Algeria

C Bouabid, Y Yamaryo-Botté, S Rabhi, H Bichiou… - Pathogens, 2022 - mdpi.com
Leishmaniasis is a protozoal vector-borne disease that affects both humans and animals. In
the Mediterranean Basin, the primary reservoir hosts of Leishmania spp. are mainly rodents …