Fusobacterium nucleatum has long been found to cause opportunistic infections and has
recently been implicated in colorectal cancer; however, it is a common member of the oral …

Chlamydia spp. are important causes of human disease for which no effective vaccine
exists. These obligate intracellular pathogens replicate in a specialized membrane …

Microbiology is at a turning point in its 120-year history. Widespread next-generation
sequencing has revealed genetic complexity among bacteria that could hardly have been …

It is estimated that approximately one billion people are at risk of infection with obligate
intracellular bacteria, but little is known about the underlying mechanisms that govern their …

Host cells use antimicrobial proteins, pathogen-restrictive compartmentalization and cell
death in their defence against intracellular pathogens. Recent work has revealed that four …

Chlamydia are obligate intracellular bacteria, characterized by a unique biphasic
developmental cycle. Specific interactions with the host cell are crucial for the bacteria's …

Abstract In 2014, the World Health Organization, the US National Institutes of Health, and
global technical partners published a comprehensive roadmap for development of new …

Evading cell death is critical for Chlamydia to maintain a replicative niche, but the underlying
mechanisms are unknown. We screened a library of Chlamydia mutants for modulators of …

Sphingolipids are a class of membrane lipids that serve as vital structural and signaling
bioactive molecules in organisms ranging from yeast to animals. Recent studies have …

All Chlamydia species are obligate intracellular bacteria that undergo a unique biphasic
developmental cycle strictly in the lumen of a membrane bound compartment, the inclusion …