We currently understand the mental effects of psychedelics to be caused by agonism or
partial agonism of 5-HT2A (and possibly 5-HT2C) receptors, and we understand that …

Serotonin is an important neuromodulator associated with a wide range of physiological
effects in the central nervous system. The exact mechanisms whereby serotonin influences …

Abstract Locusts are grasshoppers (Orthoptera: Acrididae) that are characterised by their
capacity for extreme population density-dependent polyphenism, transforming between a …

Insulin-like peptides (ILPs) and growth factors (IGFs) not only regulate development, growth,
reproduction, metabolism, stress resistance, and lifespan, but also certain behaviors and …

Liver fibrogenesis is a dynamic and highly integrated molecular, tissue and cellular process,
potentially reversible, that drives the progression of chronic liver diseases (CLD) towards …

Approved drugs have favourable or validated pharmacokinetic properties and toxicological
profiles, and the repositioning of existing drugs for new indications can potentially avoid …

Neurotransmission is the basis of neuronal communication and is critical for normal brain
development, behavior, learning, and memory. Exposure to drugs and chemicals can alter …

The word “psychedelic”(psyche (ie, the mind or soul) and delos (ie, to show)) has Greek
origin and was first coined by psychiatrist Humphry Osmond in 1956, who had been …

Tumor necrosis factor alpha (TNF-α) plays a key role in inflammation, and its production and
signaling contribute to many inflammatory related diseases. Recently, we discovered that …

The excitability of spinal motoneurons is both fundamental for motor behavior and essential
in diagnosis of neural disorders. There are two mechanisms for altering this excitability. The …