G protein-coupled receptors (GPCRs) represent the largest and most physiologically
important integral membrane protein family, and these receptors respond to a wide variety of …

Background: The guanidine group defines chemical and physicochemical properties of
many compounds of medical interest and guanidine-containing derivatives constitute a very …

Serotonin is a key neurotransmitter involved in numerous physiological processes and
serves as an important precursor for manufacturing bioactive indoleamines and alkaloids …

Spinal cord injury (SCI) is a tragic event causing irreversible losses of sensory, motor, and
autonomic functions, that may also be associated with chronic neuropathic pain. Serotonin …

Immediately after spinal cord injury (SCI), a devastating paralysis results from the loss of
brain stem and cortical innervation of spinal neurons that control movement, including a loss …

Migraine is a complex neurovascular disorder, which causes intense socioeconomic
problems worldwide. The pathophysiology of disease is enigmatic; accordingly, therapy is …

Neurotransmitters other than dopamine are recognized as having modulatory roles within
the basal ganglia and can influence the basal ganglia dopaminergic system to alter activity …

A deficient serotonergic system is associated with psychopathological behaviors in various
species, among which, feather pecking (FP) in chickens. Deficiency in the serotonergic …

Serotonin receptors play central roles in neuromodulation and are critical drug targets for
psychiatric disorders. Optical control of serotonin receptor subtypes has the potential to …

Several major developments have occurred since the last edition of Handbook of Obesity:
Clinical Applications, including new clinical trials, discoveries related to drug use, and …