Uterine fibroids (leiomyomas or myomas), benign monoclonal tumors, are the most common
benign tumors in women. Heavy or prolonged menstrual bleeding, abnormal uterine …

We review recent studies dealing with the molecular genetics and basic results of omics
analysis of uterine leiomyoma (LM)—a common benign muscle tumor of the uterus. Whole …

Highlights•Both estradiol and progesterone are essential for uterine fibroid
development.•Ovarian blockade arrests leiomyoma growth, but it has many side …

OBJECTIVE: To summarize the information regarding pathogenetic factors of leiomyoma
formation and growth, and to make a simple integrated pathogenetic view of this tumor for …

Among uterine structural abnormalities, myomas and adenomyosis represent two distinct,
though frequently coexistent entities, with a remarkable prevalence in women of …

STUDY QUESTION What are the cellular composition and single-cell transcriptomic
differences between myometrium and leiomyomas as defined by single-cell RNA …

Background: Uterine leiomyomas (fibroids) are the most common benign estrogen-
dependent tumors of premenopausal women. TGF-β3 up-regulates the synthesis of many of …

Uterine fibroids (UFs) are the most important benign neoplastic threat to women's health
worldwide, with a prevalence of up to 80% in premenopausal women, and can cause heavy …

Highlights•Race/ethnicity is the most consistent factor associated with fibroid
development.•Direct cause of genetics and the genesis of fibroids remain uncertain.•Models …

Uterine fibroids are the most common benign uterine tumors. This review examines the
different management strategies, involving mainly surgery, and evaluates them in the light of …