Coccomyxa subellipsoidea KJ (C-KJ) is a green alga with unique immunoregulatory
characteristics. Here, we investigated the mechanism underlying the modification of T cell …

Human immune system is complex and differs significantly from that of model animals. To
study the human immune system, particularly the local mucosal immune cells responding to …

Chronic kidney disease of unknown etiology was investigated for metal relations in an
endemic area by a cross-sectional study with CKD stages G1, G2, G3a, G3b, G4, G5 …

Recent advances in high-throughput measurement technologies have enabled the analysis
of molecular perturbations associated with disease phenotypes at the multi-omic level. Such …

Introduction: The hypervariable T cell receptor (TCR), created through somatic
recombination, allows for recognition of a diverse array of antigens. Single sequencing …

Background Despite the global prevalence of nonalcoholic fatty liver disease (NAFLD), its
pathophysiology remains unclear. In this study, we established highly confident …

Systemic sclerosis (SSc) is a rare autoimmune disease characterized by vasculopathy and
progressive fibrosis of the skin and internal organs. Individuals with SSc often suffer from …

The leishmaniases are globally important parasitic diseases for which no human vaccines
are currently available. To facilitate vaccine development, we conducted an open label …

From bacteria to plants and humans, the glutathione system plays a pleiotropic role in cell
defense against metabolic, oxidative and metal stresses. Glutathione (GSH), the γ-L …

Introduction: The pathological progression of non-alcoholic fatty liver disease (NAFLD) is
driven by multiple factors, and non-alcoholic steatohepatitis (NASH) represents its …