The adult CNS contains an abundant population of oligodendrocyte precursor cells (NG2+
cells) that generate oligodendrocytes and repair myelin, but how these ubiquitous …

Although microglia have long been considered as brain resident immune cells, increasing
evidence suggests that they also have physiological roles in the development of the normal …

Astrocytes are no longer seen as a homogenous population of cells. In fact, recent studies
indicate that astrocytes are morphologically and functionally diverse and play critical roles in …

Glial cell types were classified less than 100 years ago by del Rio-Hortega. For instance, he
correctly surmised that microglia in pathologic central nervous system (CNS) were …

Structural plasticity in the myelinated infrastructure of the nervous system has come to light.
Although an innate program of myelin development proceeds independent of nervous …

NG2 glia, also known as oligodendrocyte precursor cells (OPCs), play an important role in
proliferation and give rise to myelinating oligodendrocytes during early brain development …

Astrocytes participate in all essential CNS functions, including blood flow regulation, energy
metabolism, ion and water homeostasis, immune defence, neurotransmission, and adult …

Human studies consistently identify bioenergetic maladaptations in brains upon aging and
neurodegenerative disorders of aging (NDAs), such as Alzheimer's disease, Parkinson's …

Oligodendrocytes are the myelinating cells of the central nervous system (CNS). They are
the end product of a cell lineage which has to undergo a complex and precisely timed …

Many advances have been achieved in terms of understanding the molecular and cellular
mechanisms of ischemic stroke. But thus far, clinically effective neuroprotectants remain …