Neuroglial cells are fundamental for control of brain homeostasis and they represent the
intrinsic brain defence system. All forms in neuropathology therefore inevitably involve glia …

The adult mammalian brain and spinal cord contain glial precursors that express platelet-
derived growth factor receptor α subunit (PDGFRA) and the NG2 proteoglycan. These “NG2 …

Age is the most important risk factor for neurodegeneration; however, the effects of aging
and neurodegeneration on gene expression in the human brain have most often been …

Astrocytes are critical participants in synapse development and function, but their role in
synaptic plasticity is unclear. Eph receptors and their ephrin ligands have been suggested to …

Regenerative processes occurring under physiological (maintenance) and pathological
(reparative) conditions are a fundamental part of life and vary greatly among different …

Abstract Interleukin 17 (IL-17) is a signature cytokine of Th17 cells. We previously reported
that deletion of NF-κB activator 1 (Act1), the key transducer of IL-17 receptor signaling, from …

The role of glia in modulating neuronal network activity is an important question.
Oligodendrocyte precursor cells (OPC) characteristically express the transmembrane …

The phenotypic correlation between human intelligence and brain volume (BV) is
considerable (r≈ 0.40), and has been shown to be due to shared genetic factors. To further …

Summary NG2-expressing glia (NG2 glia) are a uniformly distributed and mitotically active
pool of cells in the central nervous system (CNS). In addition to serving as progenitors of …

Oligodendrocyte precursors (OLPs or 'NG2 cells') are abundant in the adult mouse brain,
where they continue to proliferate and generate new myelinating oligodendrocytes. By …