Quinolizidine-type alkaloids: chemodiversity, occurrence, and bioactivity

W Cely-Veloza, MJ Kato, E Coy-Barrera - ACS omega, 2023 - ACS Publications
Quinolizidine alkaloids (QAs) are nitrogen-containing compounds produced naturally as
specialized metabolites distributed in plants and animals (eg, frogs, sponges). The present …

An Asymmetric Hydrogenation/N‐Alkylation Sequence for a Step‐Economical Route to Indolizidines and Quinolizidines

W Zhao, W Wang, H Zhou, Q Liu, Z Ma… - Angewandte Chemie …, 2023 - Wiley Online Library
The direct catalytic asymmetric hydrogenation of pyridines for the synthesis of piperidines
remains a challenge. Herein, we report a one‐pot asymmetric hydrogenation of pyridines …

Anti-inflammatory efficacy and relevant SAR investigations of novel chiral pyrazolo isoquinoline derivatives: Design, synthesis, in-vitro, in-vivo, and computational …

M Akhtar, J Niu, Y Zhu, Z Luo, T Tian, Y Dong… - European Journal of …, 2023 - Elsevier
Isoquinoline alkaloids are a rich source of multimodal agents with distinctive structural
specificity and various pharmacological activities. In the present report, we propose a …

Emerging functions within the enzyme families of plant alkaloid biosynthesis

F Muro-Villanueva, RS Nett - Phytochemistry Reviews, 2023 - Springer
The alkaloids are a major class of nitrogen-containing plant specialized metabolites that
function as both toxic defense compounds and useful pharmaceuticals. Understanding the …

Attenuating Colorectal Cancer Using Nine Cultivars of Australian Lupin Seeds: Apoptosis Induction Triggered by Mitochondrial Reactive Oxygen Species Generation …

K Mazumder, A Aktar, S Ramasamy, B Biswas, PG Kerr… - Cells, 2023 - mdpi.com
As Australian lupin cultivars are rich sources of polyphenols, dietary fibers, high-quality
proteins, and abundant bioactive compounds with significant antioxidant, antidiabetic, and …

New Analytical Approach to Quinolizidine Alkaloids and Their Assumed Biosynthesis Pathways in Lupin Seeds

D Namdar, PPJ Mulder, E Ben-Simchon, Y Hacham… - Toxins, 2024 - mdpi.com
Alkaloids play an essential role in protecting plants against herbivores. Humans can also
benefit from the pharmacological effects of these compounds. Plants produce an immense …

Deciphering Alkaloid and Flavonoid Biosynthesis in Different Tissues of Sophora tonkinensis via Transcriptomics and Metabolomics

Y Liang, G Wei, X Liang, M Tang, H He, D Tang, Y Lin… - 2024 - researchsquare.com
Background: Sophora tonkinensis Gagnep is an important Chinese herbal medicine, with
alkaloids and flavonoids being the primary pharmacological substances. However …

Synthesis of an alkaloid inspired compound collection

R Yao - 2022 - orbit.dtu.dk
Pseudo-natural products, defined as the non-biogenic fusion of natural product fragments,
have emerged as an inspiration for rapidly identifying novel biologically active molecules …