The tendency to engage in or maintain feeding behaviour is potently influenced by the
rewarding properties of food. Affective and goal-directed behavioural responses for food …

Laboratory models, both animal and human, have made enormous contributions to our
understanding of addiction. For addictive disorders, animal models have the great …

This chapter presents new clinical applications of the prototypic GABA B receptor agonist
baclofen for the treatment of addiction by drugs of abuse, such as alcohol, cocaine, nicotine …

Rationale Many of the biochemical, physiological, and behavioral effects of ethanol are
known to be mediated by ionotropic glutamate receptors. Emerging evidence implicates …

The surge in dopamine in ventral striatal regions in response to drugs of abuse and drug-
associated stimuli is a final common pathway of addiction processes. GABA B agonists exert …

Blockade of the mGluR5 subtype of Group 1 metabotropic glutamate receptor (mGluRs)
reduces the rewarding effects of ethanol (EtOH), while the effects of mGluR1a blockade …

Translation of drug targets from preclinical studies to clinical trials has been aided by cross-
species behavioral tasks, but evidence for brain-based engagement during task …

Alcohol, tobacco and illicit drug dependence represents a serious health and social issue
within the community. As drug dependence has become more widely recognized as a …

Preclinical studies and clinical trials carried out within the past few years have provided a
premise that g-aminobutyric acid (GABA) transmission and GABAB receptors play a …

Although tobacco appears highly addictive in humans, there has been persistent
controversy about the ability of its psychoactive ingredient nicotine to induce self …