Traditional antidepressants require many weeks to reveal their therapeutic effects. However,
the widely replicated observation that a single subanesthetic dose of the N-methyl-D …

Existing treatments for major depressive disorder (MDD) usually take weeks to months to
achieve their antidepressant effects, and a significant number of patients do not have …

OBJECTIVE: Alcohol dependence may be associated with dysfunction of mesolimbic
circuitry, such that anticipation of nonalcoholic reward fails to activate the ventral striatum …

Background In healthy individuals, ketamine hydrochloride and amphetamine sulfate
produce cognitive, behavioral, and subjective effects resembling endogenous psychoses …

The past decade has seen an expansion of research and knowledge on pharmacotherapy
for the treatment of alcohol dependence. The Food and Drug Administration (FDA)-approved …

Mood disorders such as bipolar disorder and major depressive disorder are common,
chronic, and recurrent conditions affecting millions of individuals worldwide. Existing …

BackgroundThe psychosis-inducing effect of ketamine is important evidence supporting the
glutamate hypothesis of schizophrenia. However, the symptoms the drug produces have not …

BACKGROUND: A high rate of comorbidity exists between mood disorders and alcohol
dependence. Furthermore, both ketamine, a dissociative anesthetic with a recently …

Context Alcohol facilitates γ-aminobutyric acid (GABA) function, and GABA type A (GABA A)
receptor–facilitating agents suppress alcohol withdrawal symptoms. Advances in molecular …

Sažetak Major depressive disorder is the greatest burden of developed countries in the
context of morbidity caused by mental disorders. Until recent, ketamine has been mostly …